Gorham LM - Search Results

1

Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.

Askew BC, Bednar RA, Bednar B, Claremon DA, Cook JJ, McIntyre CJ, Hunt CA, Gould RJ, Lynch RJ, Lynch JJ Jr, Gaul SL, Stranieri MT, Sitko GR, Holahan MA, Glass JD, Hamill T, Gorham LM, Prueksaritanont T, Baldwin JJ, Hartman GD. Askew BC, et al. Among authors: gorham lm. J Med Chem. 1997 Jun 6;40(12):1779-88. doi: 10.1021/jm9608117. J Med Chem. 1997. PMID: 9191954

2

Disposition of L-738,167, a potent and long-acting fibrinogen receptor antagonist, in dogs. Dose-dependent pharmacokinetics.

Prueksaritanont T, Gorham LM, Naue JA, Hamill TG, Askew BC, Vyas KP. Prueksaritanont T, et al. Among authors: gorham lm. Drug Metab Dispos. 1997 Mar;25(3):355-61. Drug Metab Dispos. 1997. PMID: 9172954

3

In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.

Prueksaritanont T, Gorham LM, Breslin MJ, Hutchinson JH, Hartman GD, Vyas KP, Baillie TA. Prueksaritanont T, et al. Among authors: gorham lm. Drug Metab Dispos. 1997 Aug;25(8):978-84. Drug Metab Dispos. 1997. PMID: 9280406

4

Analysis of metabolite kinetics by deconvolution and in vivo-in vitro correlations of metabolite formation rates: studies of fibrinogen receptor antagonist ester prodrugs.

Prueksaritanont T, Gorham LM, Yeh KC. Prueksaritanont T, et al. Among authors: gorham lm. J Pharm Sci. 1997 Dec;86(12):1345-51. doi: 10.1021/js970254r. J Pharm Sci. 1997. PMID: 9423143

5

Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies.

Prueksaritanont T, Gorham LM, Ellis JD, Fernandez-Metzler C, Deluna P, Gehret JR, Strong KL, Hochman JH, Askew BC, Duggan ME, Gilbert JD, Lin JH, Vyas KP. Prueksaritanont T, et al. Among authors: gorham lm. Drug Metab Dispos. 1996 Nov;24(11):1263-71. Drug Metab Dispos. 1996. PMID: 8937862

6

Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist.

Prueksaritanont T, Lu P, Gorham L, Sternfeld F, Vyas KP. Prueksaritanont T, et al. Xenobiotica. 2000 Jan;30(1):47-59. doi: 10.1080/004982500237811. Xenobiotica. 2000. PMID: 10659950

7

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s.

Prueksaritanont T, Gorham LM, Ma B, Liu L, Yu X, Zhao JJ, Slaughter DE, Arison BH, Vyas KP. Prueksaritanont T, et al. Among authors: gorham lm. Drug Metab Dispos. 1997 Oct;25(10):1191-9. Drug Metab Dispos. 1997. PMID: 9321523

8

In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and its carboxyl ester prodrug L-775,318. Roles of efflux and metabolism.

Prueksaritanont T, DeLuna P, Gorham LM, Ma B, Cohn D, Pang J, Xu X, Leung K, Lin JH. Prueksaritanont T, et al. Among authors: gorham lm. Drug Metab Dispos. 1998 Jun;26(6):520-7. Drug Metab Dispos. 1998. PMID: 9616186

9

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells.

Prueksaritanont T, Gorham LM, Hochman JH, Tran LO, Vyas KP. Prueksaritanont T, et al. Among authors: gorham lm. Drug Metab Dispos. 1996 Jun;24(6):634-42. Drug Metab Dispos. 1996. PMID: 8781778

10

In vitro and in vivo studies on the metabolism of tirofiban.

Vickers S, Theoharides AD, Arison B, Balani SK, Cui D, Duncan CA, Ellis JD, Gorham LM, Polsky SL, Prueksaritanont T, Ramjit HG, Slaughter DE, Vyas KP. Vickers S, et al. Among authors: gorham lm. Drug Metab Dispos. 1999 Nov;27(11):1360-6. Drug Metab Dispos. 1999. PMID: 10534322

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