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Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.
Hagen SE, Prasad JV, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hamilton HW, Markoski LJ, Steinbaugh BA, Tait BD, Lunney EA, Tummino PJ, Ferguson D, Hupe D, Nouhan C, Gracheck SJ, Saunders JM, VanderRoest S. Hagen SE, et al. Among authors: domagala jm. J Med Chem. 1997 Nov 7;40(23):3707-11. doi: 10.1021/jm970522y. J Med Chem. 1997. PMID: 9371233 No abstract available.
Inhibitors of HIV protease: unique non-peptide active site templates.
Tait BD, Domagala J, Ellsworth EL, Ferguson D, Gajda C, Hupe D, Lunney EA, Tummino PJ. Tait BD, et al. J Mol Recognit. 1996 Mar-Apr;9(2):139-42. doi: 10.1002/(SICI)1099-1352(199603)9:2%3C139::AID-JMR249%3E3.0.CO;2-H. J Mol Recognit. 1996. PMID: 8877805
4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.
Tait BD, Hagen S, Domagala J, Ellsworth EL, Gajda C, Hamilton HW, Prasad JV, Ferguson D, Graham N, Hupe D, Nouhan C, Tummino PJ, Humblet C, Lunney EA, Pavlovsky A, Rubin J, Gracheck SJ, Baldwin ET, Bhat TN, Erickson JW, Gulnik SV, Liu B. Tait BD, et al. J Med Chem. 1997 Nov 7;40(23):3781-92. doi: 10.1021/jm970615f. J Med Chem. 1997. PMID: 9371244
4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.
Hagen SE, Domagala J, Gajda C, Lovdahl M, Tait BD, Wise E, Holler T, Hupe D, Nouhan C, Urumov A, Zeikus G, Zeikus E, Lunney EA, Pavlovsky A, Gracheck SJ, Saunders J, VanderRoest S, Brodfuehrer J. Hagen SE, et al. J Med Chem. 2001 Jul 5;44(14):2319-32. doi: 10.1021/jm0003844. J Med Chem. 2001. PMID: 11428926
61 results