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ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.
Donnelly-Roberts DL, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Anderson DJ, Campbell JE, Piattoni-Kaplan M, McKenna DG, Wasicak JT, Holladay MW, Williams M, Arneric SP. Donnelly-Roberts DL, et al. Among authors: briggs ca. J Pharmacol Exp Ther. 1998 May;285(2):777-86. J Pharmacol Exp Ther. 1998. PMID: 9580626
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
Malysz J, Anderson DJ, Grønlien JH, Ji J, Bunnelle WH, Håkerud M, Thorin-Hagene K, Ween H, Helfrich R, Hu M, Gubbins E, Gopalakrishnan S, Puttfarcken PS, Briggs CA, Li J, Meyer MD, Dyhring T, Ahring PK, Nielsen EØ, Peters D, Timmermann DB, Gopalakrishnan M. Malysz J, et al. Among authors: briggs ca. J Pharmacol Exp Ther. 2010 Sep 1;334(3):863-74. doi: 10.1124/jpet.110.167072. Epub 2010 May 26. J Pharmacol Exp Ther. 2010. PMID: 20504915
A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.
Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Piattoni-Kaplan M, Campbell JE, McKenna DG, Molinari E, Hettinger AM, Garvey DS, Wasicak JT, Holladay MW, Williams M, Arneric SP. Sullivan JP, et al. Among authors: briggs ca. Neuropharmacology. 1996 Jun;35(6):725-34. doi: 10.1016/0028-3908(96)84644-2. Neuropharmacology. 1996. PMID: 8887981
Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo.
Briggs CA, Anderson DJ, Brioni JD, Buccafusco JJ, Buckley MJ, Campbell JE, Decker MW, Donnelly-Roberts D, Elliott RL, Gopalakrishnan M, Holladay MW, Hui YH, Jackson WJ, Kim DJ, Marsh KC, O'Neill A, Prendergast MA, Ryther KB, Sullivan JP, Arneric SP. Briggs CA, et al. Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):231-41. doi: 10.1016/s0091-3057(96)00354-1. Pharmacol Biochem Behav. 1997. PMID: 9164577
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.
Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, Piattoni-Kaplan M, Molinari E, Campbell JE, McKenna DG, Gunn DE, Lin NH, Ryther KB, He Y, Holladay MW, Wonnacott S, Williams M, Arneric SP. Sullivan JP, et al. Among authors: briggs ca. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. J Pharmacol Exp Ther. 1997. PMID: 9336329
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.
Holladay MW, Wasicak JT, Lin NH, He Y, Ryther KB, Bannon AW, Buckley MJ, Kim DJ, Decker MW, Anderson DJ, Campbell JE, Kuntzweiler TA, Donnelly-Roberts DL, Piattoni-Kaplan M, Briggs CA, Williams M, Arneric SP. Holladay MW, et al. Among authors: briggs ca. J Med Chem. 1998 Feb 12;41(4):407-12. doi: 10.1021/jm9706224. J Med Chem. 1998. PMID: 9484491
111 results