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Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate.
Terkeltaub R, Lotz M, Johnson K, Deng D, Hashimoto S, Goldring MB, Burton D, Deftos LJ. Terkeltaub R, et al. Arthritis Rheum. 1998 Dec;41(12):2152-64. doi: 10.1002/1529-0131(199812)41:12<2152::AID-ART10>3.0.CO;2-X. Arthritis Rheum. 1998. PMID: 9870872
Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.
Lotz M, Rosen F, McCabe G, Quach J, Blanco F, Dudler J, Solan J, Goding J, Seegmiller JE, Terkeltaub R. Lotz M, et al. Among authors: terkeltaub r. Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10364-8. doi: 10.1073/pnas.92.22.10364. Proc Natl Acad Sci U S A. 1995. PMID: 7479785 Free PMC article.
Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. Relevance to calcium pyrophosphate dihydrate deposition disease.
Terkeltaub R, Rosenbach M, Fong F, Goding J. Terkeltaub R, et al. Arthritis Rheum. 1994 Jun;37(6):934-41. doi: 10.1002/art.1780370624. Arthritis Rheum. 1994. PMID: 8003067
Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-beta.
Huang R, Rosenbach M, Vaughn R, Provvedini D, Rebbe N, Hickman S, Goding J, Terkeltaub R. Huang R, et al. Among authors: terkeltaub r. J Clin Invest. 1994 Aug;94(2):560-7. doi: 10.1172/JCI117370. J Clin Invest. 1994. PMID: 8040311 Free PMC article.
273 results