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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 1
1981 3
1982 1
1983 2
1985 1
1986 1
1989 2
1991 1
1993 1
1994 1
1995 4
1996 1
1997 3
1998 2
1999 1
2000 2
2001 5
2002 4
2003 3
2004 3
2005 6
2006 9
2007 8
2008 12
2009 14
2010 15
2011 10
2012 10
2013 19
2014 13
2015 16
2016 17
2017 12
2018 9
2019 6
2020 11
2021 5
2022 4
2023 3
2024 1

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217 results

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Page 1
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Reddy A, et al. Among authors: pedersen m. Cell. 2017 Oct 5;171(2):481-494.e15. doi: 10.1016/j.cell.2017.09.027. Cell. 2017. PMID: 28985567 Free PMC article.
We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote cell growth. A prognostic model comprising these genetic alterations outperformed current established methods: cell of origin, the Int …
We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote c …
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution.
Pedersen L, Idorn M, Olofsson GH, Lauenborg B, Nookaew I, Hansen RH, Johannesen HH, Becker JC, Pedersen KS, Dethlefsen C, Nielsen J, Gehl J, Pedersen BK, Thor Straten P, Hojman P. Pedersen L, et al. Among authors: pedersen bk, pedersen ks. Cell Metab. 2016 Mar 8;23(3):554-62. doi: 10.1016/j.cmet.2016.01.011. Epub 2016 Feb 16. Cell Metab. 2016. PMID: 26895752 Free article.
In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth across five different tumor models. Microarray analysis revealed training-induced upregulation of pathways associated with immune function. ...To …
In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth acros …
Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells.
Rolver MG, Elingaard-Larsen LO, Pedersen SF. Rolver MG, et al. Among authors: pedersen sf. J Vis Exp. 2019 Jun 16;(148). doi: 10.3791/59714. J Vis Exp. 2019. PMID: 31259899
Also, the mechanical properties and cell-cell interactions of in vivo tumors are in part mimicked by this model. The specific properties and consequently the optimal growth conditions, of 3D spheroids, differ widely between different types of cancer cells. ...
Also, the mechanical properties and cell-cell interactions of in vivo tumors are in part mimicked by this model. The specific properties and …
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.
Klein AB, Nicolaisen TS, Ørtenblad N, Gejl KD, Jensen R, Fritzen AM, Larsen EL, Karstoft K, Poulsen HE, Morville T, Sahl RE, Helge JW, Lund J, Falk S, Lyngbæk M, Ellingsgaard H, Pedersen BK, Lu W, Finan B, Jørgensen SB, Seeley RJ, Kleinert M, Kiens B, Richter EA, Clemmensen C. Klein AB, et al. Among authors: pedersen bk. Nat Commun. 2021 Feb 15;12(1):1041. doi: 10.1038/s41467-021-21309-x. Nat Commun. 2021. PMID: 33589633 Free PMC article.
Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via GDNF family receptor alpha-like (GFRAL)-dependent mechanisms. ...
Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also p …
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O'Rahilly S. Cimino I, et al. Among authors: pedersen k. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. Proc Natl Acad Sci U S A. 2021. PMID: 34187898 Free PMC article.
Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness.
Czaplinska D, Ialchina R, Andersen HB, Yao J, Stigliani A, Dannesboe J, Flinck M, Chen X, Mitrega J, Gnosa SP, Dmytriyeva O, Alves F, Napp J, Sandelin A, Pedersen SF. Czaplinska D, et al. Among authors: pedersen sf. Int J Cancer. 2023 Mar 15;152(6):1210-1225. doi: 10.1002/ijc.34367. Epub 2022 Dec 1. Int J Cancer. 2023. PMID: 36408933 Free PMC article.
This pattern of acidosis-induced aggressiveness was observed in 3D spheroid culture as well as upon organotypic growth in matrigel, collagen-I and combination thereof, mimicking early and later stages of PDAC development. ...Whereas Akt inhibition decreased spheroid …
This pattern of acidosis-induced aggressiveness was observed in 3D spheroid culture as well as upon organotypic growth in matrigel, c …
3D multicellular models to study the regulation and roles of acid-base transporters in breast cancer.
Czaplinska D, Elingaard-Larsen LO, Rolver MG, Severin M, Pedersen SF. Czaplinska D, et al. Among authors: pedersen sf. Biochem Soc Trans. 2019 Dec 20;47(6):1689-1700. doi: 10.1042/BST20190131. Biochem Soc Trans. 2019. PMID: 31803922 Review.
To advance the understanding of the mechanisms and consequences of dysregulated acid-base homeostasis in breast cancer, clinically relevant models that incorporate the unique microenvironment of these tumours are required. The development of three-dimensional (3D) cell cul …
To advance the understanding of the mechanisms and consequences of dysregulated acid-base homeostasis in breast cancer, clinically relevant …
Feeding hungry stem cells.
Pedersen RA. Pedersen RA. Nat Biotechnol. 2002 Sep;20(9):882-3. doi: 10.1038/nbt0902-882. Nat Biotechnol. 2002. PMID: 12205505 No abstract available.
Voluntary wheel running can lead to modulation of immune checkpoint molecule expression.
Bay ML, Unterrainer N, Stagaard R, Pedersen KS, Schauer T, Staffeldt MM, Christensen JF, Hojman P, Pedersen BK, Gehl J. Bay ML, et al. Among authors: pedersen bk, pedersen ks. Acta Oncol. 2020 Dec;59(12):1447-1454. doi: 10.1080/0284186X.2020.1817550. Epub 2020 Sep 16. Acta Oncol. 2020. PMID: 32935602
In studies combining voluntary wheel running with PD-1 -and PD-L1 inhibitors we found significant effects of wheel running on attenuating B16 melanoma tumor growth, in line with previous studies. We did, however, not find an additive effect of combining either of th …
In studies combining voluntary wheel running with PD-1 -and PD-L1 inhibitors we found significant effects of wheel running on attenuating B1 …
Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer.
Pedersen L, Panahandeh P, Siraji MI, Knappskog S, Lønning PE, Gordillo R, Scherer PE, Molven A, Teigen K, Halberg N. Pedersen L, et al. Cancer Res. 2020 Jun 1;80(11):2163-2174. doi: 10.1158/0008-5472.CAN-19-3177. Epub 2020 Apr 14. Cancer Res. 2020. PMID: 32291319
Prominent sphingolipids include ceramides and sphingosine-1-phosphate that regulate multiple aspects of growth, apoptosis, and cellular signaling. Although a significant number of enzymatic regulators of the sphingolipid pathway have been described in detail, many remained …
Prominent sphingolipids include ceramides and sphingosine-1-phosphate that regulate multiple aspects of growth, apoptosis, and cellul …
217 results