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Lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction.
Du G, Qiao Y, Zhuo Z, Zhou J, Li X, Liu Z, Li Y, Chen H. Du G, et al. EMBO Rep. 2020 Aug 5;21(8):e49583. doi: 10.15252/embr.201949583. Epub 2020 Jul 9. EMBO Rep. 2020. PMID: 32648369 Free PMC article.
This study investigated Drosophila midguts and found a continuous downregulation of lipoic acid synthase, which encodes the key enzyme for the endogenous synthesis of alpha-lipoic acid (ALA), upon aging. ...
This study investigated Drosophila midguts and found a continuous downregulation of lipoic acid synthase, which encodes the key enzym …
TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice.
Feng C, Zhao J, Ji F, Su L, Chen Y, Jiao J. Feng C, et al. EMBO Rep. 2020 Aug 5;21(8):e49239. doi: 10.15252/embr.201949239. Epub 2020 Jun 8. EMBO Rep. 2020. PMID: 32510763 Free PMC article.
Recently, de novo mutations of transcription factor 20 (TCF20) were found in patients with autism by large-scale exome sequencing. However, how TCF20 modulates brain development and whether its dysfunction causes ASD remain unclear. Here, we show that TCF20 deficits impair …
Recently, de novo mutations of transcription factor 20 (TCF20) were found in patients with autism by large-scale exome sequencing. However, …
PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production.
Chen C, Liu Q, Chen W, Gong Z, Kang B, Sui M, Huang L, Wang YJ. Chen C, et al. EMBO Rep. 2024 Apr;25(4):2015-2044. doi: 10.1038/s44319-024-00110-z. Epub 2024 Mar 13. EMBO Rep. 2024. PMID: 38480845 Free PMC article.
Concomitantly, PRODH knockdown significantly slowed down the proteolytic degradation of multiple key mitochondrial electron transport chain complex proteins. Thus, we revealed a crucial role of PRODH in limiting mtOXPHOS and ROS production, and thereby safeguarding naive p …
Concomitantly, PRODH knockdown significantly slowed down the proteolytic degradation of multiple key mitochondrial electron transport …