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High-throughput in situ experimental phasing.
Lawrence JM, Orlans J, Evans G, Orville AM, Foadi J, Aller P. Lawrence JM, et al. Acta Crystallogr D Struct Biol. 2020 Aug 1;76(Pt 8):790-801. doi: 10.1107/S2059798320009109. Epub 2020 Jul 28. Acta Crystallogr D Struct Biol. 2020. PMID: 32744261 Free PMC article.
Droplet microfluidics for time-resolved serial crystallography.
Stubbs J, Hornsey T, Hanrahan N, Esteban LB, Bolton R, Malý M, Basu S, Orlans J, de Sanctis D, Shim JU, Shaw Stewart PD, Orville AM, Tews I, West J. Stubbs J, et al. IUCrJ. 2024 Mar 1;11(Pt 2):237-248. doi: 10.1107/S2052252524001799. IUCrJ. 2024. PMID: 38446456 Free PMC article.
Faropenem reacts with serine and metallo-β-lactamases to give multiple products.
Lucic A, Hinchliffe P, Malla TR, Tooke CL, Brem J, Calvopiña K, Lohans CT, Rabe P, McDonough MA, Armistead T, Orville AM, Spencer J, Schofield CJ. Lucic A, et al. Eur J Med Chem. 2021 Apr 5;215:113257. doi: 10.1016/j.ejmech.2021.113257. Epub 2021 Feb 9. Eur J Med Chem. 2021. PMID: 33618159 Free PMC article.
A versatile approach to high-density microcrystals in lipidic cubic phase for room-temperature serial crystallography.
Birch J, Kwan TOC, Judge PJ, Axford D, Aller P, Butryn A, Reis RI, Bada Juarez JF, Vinals J, Owen RL, Nango E, Tanaka R, Tono K, Joti Y, Tanaka T, Owada S, Sugahara M, Iwata S, Orville AM, Watts A, Moraes I. Birch J, et al. J Appl Crystallogr. 2023 Aug 18;56(Pt 5):1361-1370. doi: 10.1107/S1600576723006428. eCollection 2023 Oct 1. J Appl Crystallogr. 2023. PMID: 37791355 Free PMC article.
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography.
Butryn A, Simon PS, Aller P, Hinchliffe P, Massad RN, Leen G, Tooke CL, Bogacz I, Kim IS, Bhowmick A, Brewster AS, Devenish NE, Brem J, Kamps JJAG, Lang PA, Rabe P, Axford D, Beale JH, Davy B, Ebrahim A, Orlans J, Storm SLS, Zhou T, Owada S, Tanaka R, Tono K, Evans G, Owen RL, Houle FA, Sauter NK, Schofield CJ, Spencer J, Yachandra VK, Yano J, Kern JF, Orville AM. Butryn A, et al. Nat Commun. 2021 Jul 22;12(1):4461. doi: 10.1038/s41467-021-24757-7. Nat Commun. 2021. PMID: 34294694 Free PMC article.
13 results