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Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.
Jall S, De Angelis M, Lundsgaard AM, Fritzen AM, Nicolaisen TS, Klein AB, Novikoff A, Sachs S, Richter EA, Kiens B, Schramm KW, Tschöp MH, Stemmer K, Clemmensen C, Müller TD, Kleinert M. Jall S, et al. Diabetologia. 2020 Jun;63(6):1236-1247. doi: 10.1007/s00125-020-05117-4. Epub 2020 Mar 6. Diabetologia. 2020. PMID: 32140744 Free PMC article.
Obesity leads to impairments in the morphology and organization of human skeletal muscle lipid droplets and mitochondrial networks, which are resolved with gastric bypass surgery-induced improvements in insulin sensitivity.
Kristensen MD, Petersen SM, Møller KE, Lund MT, Hansen M, Hansen CN, Courraud J, Helge JW, Dela F, Prats C. Kristensen MD, et al. Acta Physiol (Oxf). 2018 Dec;224(4):e13100. doi: 10.1111/apha.13100. Epub 2018 Jun 10. Acta Physiol (Oxf). 2018. PMID: 29791782
The 8th meeting of North European Young Diabetologists.
Dirksen C, van Dijk PR, Whicher C, Janssen AWM, Lund A. Dirksen C, et al. Diabet Med. 2020 Aug;37(8):1403. doi: 10.1111/dme.14138. Epub 2019 Sep 26. Diabet Med. 2020. PMID: 31532014 No abstract available.
Hyperpolarized [1-13 C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model.
Tougaard RS, Szocska Hansen ES, Laustsen C, Nørlinger TS, Mikkelsen E, Lindhardt J, Nielsen PM, Bertelsen LB, Schroeder M, Bøtker HE, Kim WY, Wiggers H, Stødkilde-Jørgensen H. Tougaard RS, et al. Magn Reson Med. 2019 Apr;81(4):2655-2665. doi: 10.1002/mrm.27560. Epub 2018 Nov 2. Magn Reson Med. 2019. PMID: 30387898 Free article.
A randomised, double-blind, placebo-controlled trial of metformin on myocardial efficiency in insulin-resistant chronic heart failure patients without diabetes.
Larsen AH, Jessen N, Nørrelund H, Tolbod LP, Harms HJ, Feddersen S, Nielsen F, Brøsen K, Hansson NH, Frøkiaer J, Poulsen SH, Sörensen J, Wiggers H. Larsen AH, et al. Eur J Heart Fail. 2020 Sep;22(9):1628-1637. doi: 10.1002/ejhf.1656. Epub 2019 Dec 21. Eur J Heart Fail. 2020. PMID: 31863557 Free article. Clinical Trial.