HL077814/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2006	1
2008	2
2009	1
2012	2
2013	2
2014	2
2015	1
2016	1
2017	1
2019	1
2024	0

1

Dysregulation of RNA polymerase I transcription during disease.

Hannan KM, Sanij E, Rothblum LI, Hannan RD, Pearson RB. Hannan KM, et al. Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):342-60. doi: 10.1016/j.bbagrm.2012.10.014. Epub 2012 Nov 12. Biochim Biophys Acta. 2013. PMID: 23153826 Free PMC article. Review.

2

Regulation of the association of the PAF53/PAF49 heterodimer with RNA polymerase I.

Penrod Y, Rothblum K, Cavanaugh A, Rothblum LI. Penrod Y, et al. Gene. 2015 Feb 1;556(1):61-7. doi: 10.1016/j.gene.2014.09.022. Epub 2014 Sep 16. Gene. 2015. PMID: 25225125 Free PMC article.

3

Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains.

McNamar R, Abu-Adas Z, Rothblum K, Knutson BA, Rothblum LI. McNamar R, et al. J Biol Chem. 2019 Dec 27;294(52):19907-19922. doi: 10.1074/jbc.RA119.009902. Epub 2019 Nov 14. J Biol Chem. 2019. PMID: 31727736 Free PMC article.

4

Characterization of the interactions of mammalian RNA polymerase I associated proteins PAF53 and PAF49.

Penrod Y, Rothblum K, Rothblum LI. Penrod Y, et al. Biochemistry. 2012 Aug 21;51(33):6519-26. doi: 10.1021/bi300408q. Epub 2012 Aug 8. Biochemistry. 2012. PMID: 22849406 Free PMC article.

5

PAF53 is essential in mammalian cells: CRISPR/Cas9 fails to eliminate PAF53 expression.

Rothblum LI, Rothblum K, Chang E. Rothblum LI, et al. Gene. 2017 May 15;612:55-60. doi: 10.1016/j.gene.2016.12.023. Epub 2016 Dec 29. Gene. 2017. PMID: 28042089 Free PMC article.

6

Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3.

Rothblum K, Hu Q, Penrod Y, Rothblum LI. Rothblum K, et al. Mol Cancer Res. 2014 Nov;12(11):1586-96. doi: 10.1158/1541-7786.MCR-14-0229. Epub 2014 Jul 17. Mol Cancer Res. 2014. PMID: 25033839 Free PMC article.

7

UBF levels determine the number of active ribosomal RNA genes in mammals.

Sanij E, Poortinga G, Sharkey K, Hung S, Holloway TP, Quin J, Robb E, Wong LH, Thomas WG, Stefanovsky V, Moss T, Rothblum L, Hannan KM, McArthur GA, Pearson RB, Hannan RD. Sanij E, et al. J Cell Biol. 2008 Dec 29;183(7):1259-74. doi: 10.1083/jcb.200805146. Epub 2008 Dec 22. J Cell Biol. 2008. PMID: 19103806 Free PMC article.

8

DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.

Stepanchick A, Zhi H, Cavanaugh AH, Rothblum K, Schneider DA, Rothblum LI. Stepanchick A, et al. J Biol Chem. 2013 Mar 29;288(13):9135-44. doi: 10.1074/jbc.M112.444265. Epub 2013 Feb 7. J Biol Chem. 2013. PMID: 23393135 Free PMC article.

9

Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I.

Cavanaugh AH, Evans A, Rothblum LI. Cavanaugh AH, et al. Gene Expr. 2008;14(3):131-47. Gene Expr. 2008. PMID: 18590050 Free PMC article.

10

Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.

DuRose JB, Scheuner D, Kaufman RJ, Rothblum LI, Niwa M. DuRose JB, et al. Mol Cell Biol. 2009 Aug;29(15):4295-307. doi: 10.1128/MCB.00260-09. Epub 2009 May 26. Mol Cell Biol. 2009. PMID: 19470760 Free PMC article.

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