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Lack of plakoglobin in epidermis leads to keratoderma.
Li D, Zhang W, Liu Y, Haneline LS, Shou W. Li D, et al. J Biol Chem. 2012 Mar 23;287(13):10435-10443. doi: 10.1074/jbc.M111.299669. Epub 2012 Feb 7. J Biol Chem. 2012. PMID: 22315228 Free PMC article.
Smad7 is required for the development and function of the heart.
Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, Zhu W, Bu G, Jin T, Wang Z, Zhang X, Chen J, Field LJ, Rubart M, Shou W, Chen Y. Chen Q, et al. J Biol Chem. 2009 Jan 2;284(1):292-300. doi: 10.1074/jbc.M807233200. Epub 2008 Oct 24. J Biol Chem. 2009. PMID: 18952608 Free PMC article.
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