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CLL dedifferentiation to clonally related myeloid cells.
Dong Q, Xiu Y, Bossler A, Syrbu S, Wang H, Xue W, Zhao J, Li Q, Jin M, Wang L, Boyce B, Sakr H, Ansari MQ, Zhao C. Dong Q, et al. Blood Adv. 2020 Dec 22;4(24):6169-6174. doi: 10.1182/bloodadvances.2020002726. Blood Adv. 2020. PMID: 33351112 Free PMC article.
HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.
Dong Q, Xiu Y, Wang Y, Hodgson C, Borcherding N, Jordan C, Buchanan J, Taylor E, Wagner B, Leidinger M, Holman C, Thiele DJ, O'Brien S, Xue HH, Zhao J, Li Q, Meyerson H, Boyce BF, Zhao C. Dong Q, et al. Nat Commun. 2022 Oct 16;13(1):6107. doi: 10.1038/s41467-022-33861-1. Nat Commun. 2022. PMID: 36245043 Free PMC article.
Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion.
Xiu Y, Dong Q, Fu L, Bossler A, Tang X, Boyce B, Borcherding N, Leidinger M, Sardina JL, Xue HH, Li Q, Feldman A, Aifantis I, Boccalatte F, Wang L, Jin M, Khoury J, Wang W, Hu S, Yuan Y, Wang E, Yuan J, Janz S, Colgan J, Habelhah H, Waldschmidt T, Müschen M, Bagg A, Darbro B, Zhao C. Xiu Y, et al. Blood. 2020 Jan 9;135(2):108-120. doi: 10.1182/blood.2019001438. Blood. 2020. PMID: 31697816 Free PMC article.