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Fumarate is a terminal electron acceptor in the mammalian electron transport chain.
Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM. Spinelli JB, et al. Science. 2021 Dec 3;374(6572):1227-1237. doi: 10.1126/science.abi7495. Epub 2021 Dec 2. Science. 2021. PMID: 34855504 Free PMC article.
PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle.
Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC. Yoon H, et al. Cell Metab. 2020 Aug 4;32(2):215-228.e7. doi: 10.1016/j.cmet.2020.06.017. Epub 2020 Jul 13. Cell Metab. 2020. PMID: 32663458 Free PMC article.
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.
van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. van Gastel N, et al. Cell Metab. 2020 Sep 1;32(3):391-403.e6. doi: 10.1016/j.cmet.2020.07.009. Epub 2020 Aug 6. Cell Metab. 2020. PMID: 32763164 Free PMC article.