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Telomere dysfunction causes alveolar stem cell failure.
Alder JK, Barkauskas CE, Limjunyawong N, Stanley SE, Kembou F, Tuder RM, Hogan BL, Mitzner W, Armanios M. Alder JK, et al. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5099-104. doi: 10.1073/pnas.1504780112. Epub 2015 Apr 3. Proc Natl Acad Sci U S A. 2015. PMID: 25840590 Free PMC article.
Telomerase mutations in smokers with severe emphysema.
Stanley SE, Chen JJ, Podlevsky JD, Alder JK, Hansel NN, Mathias RA, Qi X, Rafaels NM, Wise RA, Silverman EK, Barnes KC, Armanios M. Stanley SE, et al. J Clin Invest. 2015 Feb;125(2):563-70. doi: 10.1172/JCI78554. Epub 2014 Dec 22. J Clin Invest. 2015. PMID: 25562321 Free PMC article. Clinical Trial.