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High-throughput hit-squad tackles trypanosomes.
Cook AD, Higgins MK. Cook AD, et al. Trends Parasitol. 2021 Sep;37(9):772-774. doi: 10.1016/j.pt.2021.07.005. Epub 2021 Jul 24. Trends Parasitol. 2021. PMID: 34315657 Review.
O-h what a surprise.
Carrington M, Higgins MK. Carrington M, et al. Nat Microbiol. 2018 Aug;3(8):856-857. doi: 10.1038/s41564-018-0211-x. Nat Microbiol. 2018. PMID: 30046170 No abstract available.
A Receptor's Tale: An Eon in the Life of a Trypanosome Receptor.
Higgins MK, Lane-Serff H, MacGregor P, Carrington M. Higgins MK, et al. PLoS Pathog. 2017 Jan 26;13(1):e1006055. doi: 10.1371/journal.ppat.1006055. eCollection 2017 Jan. PLoS Pathog. 2017. PMID: 28125726 Free PMC article. Review.
Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M. Macleod OJS, et al. Nat Commun. 2022 Aug 29;13(1):5085. doi: 10.1038/s41467-022-32728-9. Nat Commun. 2022. PMID: 36038546 Free PMC article.
A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.
MacGregor P, Gonzalez-Munoz AL, Jobe F, Taylor MC, Rust S, Sandercock AM, Macleod OJS, Van Bocxlaer K, Francisco AF, D'Hooge F, Tiberghien A, Barry CS, Howard P, Higgins MK, Vaughan TJ, Minter R, Carrington M. MacGregor P, et al. PLoS Negl Trop Dis. 2019 May 23;13(5):e0007373. doi: 10.1371/journal.pntd.0007373. eCollection 2019 May. PLoS Negl Trop Dis. 2019. PMID: 31120889 Free PMC article.