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Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway.
Duffield-Lillico AJ, Boyle JO, Zhou XK, Ghosh A, Butala GS, Subbaramaiah K, Newman RA, Morrow JD, Milne GL, Dannenberg AJ. Duffield-Lillico AJ, et al. Cancer Prev Res (Phila). 2009 Apr;2(4):322-9. doi: 10.1158/1940-6207.CAPR-09-0005. Epub 2009 Mar 31. Cancer Prev Res (Phila). 2009. PMID: 19336727 Free PMC article. Clinical Trial.
Elevated levels of urinary prostaglandin e metabolite indicate a poor prognosis in ever smoker head and neck squamous cell carcinoma patients.
Kekatpure VD, Boyle JO, Zhou XK, Duffield-Lillico AJ, Gross ND, Lee NY, Subbaramaiah K, Morrow JD, Milne G, Lippman SM, Dannenberg AJ. Kekatpure VD, et al. Cancer Prev Res (Phila). 2009 Nov;2(11):957-65. doi: 10.1158/1940-6207.CAPR-09-0093. Epub 2009 Oct 20. Cancer Prev Res (Phila). 2009. PMID: 19843689 Free PMC article.