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The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation.
Immunity. 2021 Feb 9;54(2):308-323.e6. doi: 10.1016/j.immuni.2020.12.010. Epub 2021 Jan 8.
Immunity. 2021.
PMID: 33421362
Free PMC article.
IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system.
Seyedsadr M, Wang Y, Elzoheiry M, Shree Gopal S, Jang S, Duran G, Chervoneva I, Kasimoglou E, Wrobel JA, Hwang D, Garifallou J, Zhang X, Khan TH, Lorenz U, Su M, Ting JP, Broux B, Rostami A, Miskin D, Markovic-Plese S.
Seyedsadr M, et al.
Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2221007120. doi: 10.1073/pnas.2221007120. Epub 2023 Jun 20.
Proc Natl Acad Sci U S A. 2023.
PMID: 37339207
Free PMC article.
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Therapeutic Effect of Anti-CD52 Monoclonal Antibody in Multiple Sclerosis and Its Animal Models Is Mediated via T Regulatory Cells.
Kiapour N, Wu B, Wang Y, Seyedsadr M, Kapoor S, Zhang X, Elzoheiry M, Kasimoglu E, Wan Y, Markovic-Plese S.
Kiapour N, et al.
J Immunol. 2022 Jul 1;209(1):49-56. doi: 10.4049/jimmunol.2100176. Epub 2022 Jun 24.
J Immunol. 2022.
PMID: 35750335
Free PMC article.
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IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.
Zhang X, Kiapour N, Kapoor S, Khan T, Thamilarasan M, Tao Y, Cohen S, Miller R, Sobel RA, Markovic-Plese S.
Zhang X, et al.
J Immunol. 2019 Sep 1;203(5):1142-1150. doi: 10.4049/jimmunol.1900311. Epub 2019 Jul 24.
J Immunol. 2019.
PMID: 31341075
Free PMC article.
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STING Agonist Mitigates Experimental Autoimmune Encephalomyelitis by Stimulating Type I IFN-Dependent and -Independent Immune-Regulatory Pathways.
Johnson BM, Uchimura T, Gallovic MD, Thamilarasan M, Chou WC, Gibson SA, Deng M, Tam JW, Batty CJ, Williams J, Matsushima GK, Bachelder EM, Ainslie KM, Markovic-Plese S, Ting JP.
Johnson BM, et al.
J Immunol. 2021 May 1;206(9):2015-2028. doi: 10.4049/jimmunol.2001317. Epub 2021 Apr 5.
J Immunol. 2021.
PMID: 33820855
Free PMC article.
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