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Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo.
Cancer Res. 2009 Jun 1;69(11):4791-9. doi: 10.1158/0008-5472.CAN-09-0615.
Cancer Res. 2009.
PMID: 19487291
Free PMC article.
Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine.
Stolworthy TS, Korkegian AM, Willmon CL, Ardiani A, Cundiff J, Stoddard BL, Black ME.
Stolworthy TS, et al.
J Mol Biol. 2008 Mar 28;377(3):854-69. doi: 10.1016/j.jmb.2008.01.002. Epub 2008 Jan 11.
J Mol Biol. 2008.
PMID: 18291415
Free PMC article.
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