R01 GM105993/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2013	2
2015	1
2016	3
2018	1
2019	1
2020	1
2022	1
2023	1
2024	0

1

Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.

Sprang SR. Sprang SR. Biopolymers. 2016 Aug;105(8):449-62. doi: 10.1002/bip.22836. Biopolymers. 2016. PMID: 26996924 Free PMC article. Review.

2

An acid test for g proteins.

Sprang SR. Sprang SR. Mol Cell. 2013 Aug 22;51(4):405-6. doi: 10.1016/j.molcel.2013.08.012. Mol Cell. 2013. PMID: 23973370 Free PMC article.

3

Atypical activation of the G protein Gα_q by the oncogenic mutation Q209P.

Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M. Maziarz M, et al. J Biol Chem. 2018 Dec 21;293(51):19586-19599. doi: 10.1074/jbc.RA118.005291. Epub 2018 Oct 23. J Biol Chem. 2018. PMID: 30352874 Free PMC article.

4

Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A.

Zeng B, Mou TC, Doukov TI, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F, Sprang SR. Zeng B, et al. Structure. 2019 Jul 2;27(7):1137-1147.e5. doi: 10.1016/j.str.2019.04.013. Epub 2019 May 30. Structure. 2019. PMID: 31155309 Free PMC article.

5

Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.

Kant R, Zeng B, Thomas CJ, Bothner B, Sprang SR. Kant R, et al. Elife. 2016 Dec 23;5:e19238. doi: 10.7554/eLife.19238. Elife. 2016. PMID: 28008853 Free PMC article.

6

The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A.

Muñoz-Reyes D, McClelland LJ, Arroyo-Urea S, Sánchez-Yepes S, Sabín J, Pérez-Suárez S, Menendez M, Mansilla A, García-Nafría J, Sprang S, Sanchez-Barrena MJ. Muñoz-Reyes D, et al. Elife. 2023 Nov 29;12:e86151. doi: 10.7554/eLife.86151. Elife. 2023. PMID: 38018500 Free PMC article.

7

Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.

Black LA, Thomas CJ, Nix GN, Terwilliger MC, Sprang SR, Ross JBA. Black LA, et al. Biophys J. 2016 Aug 23;111(4):722-731. doi: 10.1016/j.bpj.2016.07.021. Biophys J. 2016. PMID: 27558716 Free PMC article.

8

The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.

Van Eps N, Thomas CJ, Hubbell WL, Sprang SR. Van Eps N, et al. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1404-9. doi: 10.1073/pnas.1423878112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605908 Free PMC article.

9

Application of sulfur SAD to small crystals with a large asymmetric unit and anomalous substructure.

Mou TC, Zeng B, Doukov TI, Sprang SR. Mou TC, et al. Acta Crystallogr D Struct Biol. 2022 Aug 1;78(Pt 8):1021-1031. doi: 10.1107/S2059798322005848. Epub 2022 Jul 14. Acta Crystallogr D Struct Biol. 2022. PMID: 35916226 Free PMC article.

10

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1.

McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR. McClelland LJ, et al. Nat Commun. 2020 Feb 26;11(1):1077. doi: 10.1038/s41467-020-14943-4. Nat Commun. 2020. PMID: 32103024 Free PMC article.

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