R01CA109025/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2007	2
2008	6
2009	2
2010	2
2011	4
2012	2
2013	1
2014	1
2024	0

1

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Kawamoto SA, Gao W, Yi H, Qin D, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Anal Biochem. 2008 Mar 1;374(1):87-98. doi: 10.1016/j.ab.2007.10.032. Epub 2007 Nov 20. Anal Biochem. 2008. PMID: 18023397

2

Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.

Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S. Sun H, et al. J Med Chem. 2010 Sep 9;53(17):6361-7. doi: 10.1021/jm100487z. J Med Chem. 2010. PMID: 20684551 Free PMC article.

3

Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction.

Yang CY, Sun H, Chen J, Nikolovska-Coleska Z, Wang S. Yang CY, et al. J Am Chem Soc. 2009 Sep 30;131(38):13709-21. doi: 10.1021/ja9039373. J Am Chem Soc. 2009. PMID: 19736924 Free PMC article.

4

Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.

Sun H, Lu J, Liu L, Yang CY, Wang S. Sun H, et al. ACS Chem Biol. 2014 Apr 18;9(4):994-1002. doi: 10.1021/cb400889a. Epub 2014 Feb 12. ACS Chem Biol. 2014. PMID: 24521431 Free PMC article.

5

Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.

Peng Y, Sun H, Lu J, Liu L, Cai Q, Shen R, Yang CY, Yi H, Wang S. Peng Y, et al. J Med Chem. 2012 Jan 12;55(1):106-14. doi: 10.1021/jm201072x. Epub 2011 Dec 7. J Med Chem. 2012. PMID: 22148838

6

Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Yang CY, Qiu S, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Biochemistry. 2008 Sep 16;47(37):9811-24. doi: 10.1021/bi800785y. Epub 2008 Aug 22. Biochemistry. 2008. PMID: 18717598 Free PMC article.

7

A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.

Sheng R, Sun H, Liu L, Lu J, McEachern D, Wang G, Wen J, Min P, Du Z, Lu H, Kang S, Guo M, Yang D, Wang S. Sheng R, et al. J Med Chem. 2013 May 23;56(10):3969-79. doi: 10.1021/jm400216d. Epub 2013 May 7. J Med Chem. 2013. PMID: 23651223 Free PMC article.

8

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, Qiu S, Tomita Y, Ueda Y, Jiang S, Krajewski K, Roller PP, Stuckey JA, Wang S. Sun H, et al. J Am Chem Soc. 2007 Dec 12;129(49):15279-94. doi: 10.1021/ja074725f. Epub 2007 Nov 14. J Am Chem Soc. 2007. PMID: 17999504 Free PMC article.

9

A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.

Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang CY, Miller R, Yi H, Zhang T, Sun D, Kang S, Guo M, Leopold L, Yang D, Wang S. Cai Q, et al. J Med Chem. 2011 Apr 28;54(8):2714-26. doi: 10.1021/jm101505d. Epub 2011 Mar 28. J Med Chem. 2011. PMID: 21443232 Free PMC article.

10

Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment.

Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S. Lu J, et al. Mol Cancer Ther. 2011 May;10(5):902-14. doi: 10.1158/1535-7163.MCT-10-0864. Epub 2011 Mar 3. Mol Cancer Ther. 2011. PMID: 21372226 Free PMC article.

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