R21 MH102548/MH/NIMH NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	2
2017	3
2018	4
2022	2
2023	1
2024	0

1

Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.

Fisher NM, Seto M, Lindsley CW, Niswender CM. Fisher NM, et al. Front Mol Neurosci. 2018 Oct 23;11:387. doi: 10.3389/fnmol.2018.00387. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30405350 Free PMC article. Review.

2

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ. Lindsley CW, et al. Chem Rev. 2016 Jun 8;116(11):6707-41. doi: 10.1021/acs.chemrev.5b00656. Epub 2016 Feb 16. Chem Rev. 2016. PMID: 26882314 Free PMC article. Review.

3

Development and profiling of mGlu₇ NAMs with a range of saturable inhibition of agonist responses in vitro.

Reed CW, Rodriguez AL, Kalbfleisch JJ, Seto M, Jenkins MT, Blobaum AL, Chang S, Lindsley CW, Niswender CM. Reed CW, et al. Bioorg Med Chem Lett. 2022 Oct 15;74:128923. doi: 10.1016/j.bmcl.2022.128923. Epub 2022 Aug 6. Bioorg Med Chem Lett. 2022. PMID: 35944850 Free PMC article.

4

Persistent challenges in the development of an mGlu₇ PAM in vivo tool compound: The discovery of VU6046980.

Kalbfleisch JJ, Rodriguez AL, Lei X, Weiss K, Blobaum AL, Boutaud O, Niswender CM, Lindsley CW. Kalbfleisch JJ, et al. Bioorg Med Chem Lett. 2023 Jan 15;80:129106. doi: 10.1016/j.bmcl.2022.129106. Epub 2022 Dec 15. Bioorg Med Chem Lett. 2023. PMID: 36528230 Free PMC article.

5

Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.

Stansley BJ, Fisher NM, Gogliotti RG, Lindsley CW, Conn PJ, Niswender CM. Stansley BJ, et al. Cereb Cortex. 2018 Dec 1;28(12):4291-4304. doi: 10.1093/cercor/bhx282. Cereb Cortex. 2018. PMID: 29136107 Free PMC article.

6

Discovery of VU6005649, a CNS Penetrant mGlu_7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines.

Abe M, Seto M, Gogliotti RG, Loch MT, Bollinger KA, Chang S, Engelberg EM, Luscombe VB, Harp JM, Bubser M, Engers DW, Jones CK, Rodriguez AL, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Abe M, et al. ACS Med Chem Lett. 2017 Sep 1;8(10):1110-1115. doi: 10.1021/acsmedchemlett.7b00317. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057060 Free PMC article.

7

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M₄ Muscarinic Receptor as a Novel Therapeutic Target.

Gogliotti RG, Fisher NM, Stansley BJ, Jones CK, Lindsley CW, Conn PJ, Niswender CM. Gogliotti RG, et al. J Pharmacol Exp Ther. 2018 May;365(2):291-300. doi: 10.1124/jpet.117.246991. Epub 2018 Mar 9. J Pharmacol Exp Ther. 2018. PMID: 29523700 Free PMC article.

8

mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.

Gogliotti RG, Senter RK, Rook JM, Ghoshal A, Zamorano R, Malosh C, Stauffer SR, Bridges TM, Bartolome JM, Daniels JS, Jones CK, Lindsley CW, Conn PJ, Niswender CM. Gogliotti RG, et al. Hum Mol Genet. 2016 May 15;25(10):1990-2004. doi: 10.1093/hmg/ddw074. Epub 2016 Mar 2. Hum Mol Genet. 2016. PMID: 26936821 Free PMC article.

9

Genetic Reduction or Negative Modulation of mGlu₇ Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.

Fisher NM, Gogliotti RG, Vermudez SAD, Stansley BJ, Conn PJ, Niswender CM. Fisher NM, et al. ACS Chem Neurosci. 2018 Sep 19;9(9):2210-2217. doi: 10.1021/acschemneuro.7b00414. Epub 2017 Dec 14. ACS Chem Neurosci. 2018. PMID: 29227625 Free PMC article.

10

mGlu₇ potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

Gogliotti RG, Senter RK, Fisher NM, Adams J, Zamorano R, Walker AG, Blobaum AL, Engers DW, Hopkins CR, Daniels JS, Jones CK, Lindsley CW, Xiang Z, Conn PJ, Niswender CM. Gogliotti RG, et al. Sci Transl Med. 2017 Aug 16;9(403):eaai7459. doi: 10.1126/scitranslmed.aai7459. Sci Transl Med. 2017. PMID: 28814546 Free PMC article.

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