R21 MH104471/MH/NIMH NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2015	1
2016	2
2017	3
2018	4
2019	1
2020	1
2021	1
2022	1
2024	0

1

Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder.

Lyman KA, Han Y, Chetkovich DM. Lyman KA, et al. Expert Opin Ther Targets. 2017 Mar;21(3):235-237. doi: 10.1080/14728222.2017.1287899. Expert Opin Ther Targets. 2017. PMID: 28127990 Free PMC article. No abstract available.

2

The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels.

Han Y, Lyman KA, Foote KM, Chetkovich DM. Han Y, et al. Channels (Austin). 2020 Dec;14(1):110-122. doi: 10.1080/19336950.2020.1740501. Channels (Austin). 2020. PMID: 32189562 Free PMC article. Review.

3

Discovery of a small-molecule inhibitor of the TRIP8b-HCN interaction with efficacy in neurons.

Han Y, Iyamu ID, Clutter MR, Mishra RK, Lyman KA, Zhou C, Michailidis I, Xia MY, Sharma H, Luan CH, Schiltz GE, Chetkovich DM. Han Y, et al. J Biol Chem. 2022 Jul;298(7):102069. doi: 10.1016/j.jbc.2022.102069. Epub 2022 May 24. J Biol Chem. 2022. PMID: 35623388 Free PMC article.

4

Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.

Yun S, Reynolds RP, Petrof I, White A, Rivera PD, Segev A, Gibson AD, Suarez M, DeSalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ. Yun S, et al. Nat Med. 2018 May;24(5):658-666. doi: 10.1038/s41591-018-0002-1. Epub 2018 Apr 16. Nat Med. 2018. PMID: 29662202 Free PMC article.

5

HCN channels in the hippocampus regulate active coping behavior.

Fisher DW, Han Y, Lyman KA, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM. Fisher DW, et al. J Neurochem. 2018 Sep;146(6):753-766. doi: 10.1111/jnc.14539. Epub 2018 Aug 9. J Neurochem. 2018. PMID: 29953635 Free PMC article.

6

HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects.

Han Y, Heuermann RJ, Lyman KA, Fisher D, Ismail QA, Chetkovich DM. Han Y, et al. Mol Psychiatry. 2017 Mar;22(3):458-465. doi: 10.1038/mp.2016.99. Epub 2016 Jul 12. Mol Psychiatry. 2017. PMID: 27400855 Free PMC article.

7

Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior.

Lyman KA, Han Y, Zhou C, Renteria I, Besing GL, Kurz JE, Chetkovich DM. Lyman KA, et al. Sci Transl Med. 2021 Nov 24;13(621):eabl4580. doi: 10.1126/scitranslmed.abl4580. Epub 2021 Nov 24. Sci Transl Med. 2021. PMID: 34818058 Free PMC article.

8

Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells.

Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C. Frigerio F, et al. Mol Neurobiol. 2018 Sep;55(9):7500-7511. doi: 10.1007/s12035-018-0915-1. Epub 2018 Feb 9. Mol Neurobiol. 2018. PMID: 29427087 Free PMC article.

9

Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.

Fisher DW, Luu P, Agarwal N, Kurz JE, Chetkovich DM. Fisher DW, et al. PLoS One. 2018 Feb 21;13(2):e0193012. doi: 10.1371/journal.pone.0193012. eCollection 2018. PLoS One. 2018. PMID: 29466436 Free PMC article.

10

Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.

Han Y, Lyman K, Clutter M, Schiltz GE, Ismail QA, Prados DB, Luan CH, Chetkovich DM. Han Y, et al. J Biomol Screen. 2015 Oct;20(9):1124-31. doi: 10.1177/1087057115589590. Epub 2015 Jun 4. J Biomol Screen. 2015. PMID: 26045196 Free PMC article.

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