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Page 1
Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.
Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP. Crosby JR, et al. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1670-8. doi: 10.1161/ATVBAHA.113.301282. Epub 2013 Apr 4. Arterioscler Thromb Vasc Biol. 2013. PMID: 23559626 Free PMC article.
Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.
Lorentz CU, Verbout NG, Wallisch M, Hagen MW, Shatzel JJ, Olson SR, Puy C, Hinds MT, McCarty OJT, Gailani D, Gruber A, Tucker EI. Lorentz CU, et al. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809. doi: 10.1161/ATVBAHA.118.312328. Arterioscler Thromb Vasc Biol. 2019. PMID: 30700130 Free PMC article. Clinical Trial.
Factor XII inhibition reduces thrombus formation in a primate thrombosis model.
Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun MF, McCarty OJ, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D. Matafonov A, et al. Blood. 2014 Mar 13;123(11):1739-46. doi: 10.1182/blood-2013-04-499111. Epub 2014 Jan 9. Blood. 2014. PMID: 24408325 Free PMC article.
Excess of heme induces tissue factor-dependent activation of coagulation in mice.
Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R. Sparkenbaugh EM, et al. Haematologica. 2015 Mar;100(3):308-14. doi: 10.3324/haematol.2014.114728. Epub 2015 Jan 16. Haematologica. 2015. PMID: 25596265 Free PMC article.