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Family-based samples can play an important role in genetic association studies.
Lange EM, Sun J, Lange LA, Zheng SL, Duggan D, Carpten JD, Gronberg H, Isaacs WB, Xu J, Chang BL. Lange EM, et al. Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2208-14. doi: 10.1158/1055-9965.EPI-08-0183. Cancer Epidemiol Biomarkers Prev. 2008. PMID: 18768484 Free PMC article.
Sequence variants at 22q13 are associated with prostate cancer risk.
Sun J, Zheng SL, Wiklund F, Isaacs SD, Li G, Wiley KE, Kim ST, Zhu Y, Zhang Z, Hsu FC, Turner AR, Stattin P, Liu W, Kim JW, Duggan D, Carpten J, Isaacs W, Grönberg H, Xu J, Chang BL. Sun J, et al. Cancer Res. 2009 Jan 1;69(1):10-5. doi: 10.1158/0008-5472.CAN-08-3464. Cancer Res. 2009. PMID: 19117981 Free PMC article.