STEEP mediates STING ER exit and activation of signaling.
Zhang BC, Nandakumar R, Reinert LS, Huang J, Laustsen A, Gao ZL, Sun CL, Jensen SB, Troldborg A, Assil S, Berthelsen MF, Scavenius C, Zhang Y, Windross SJ, Olagnier D, Prabakaran T, Bodda C, Narita R, Cai Y, Zhang CG, Stenmark H, Doucet CM, Noda T, Guo Z, Goldbach-Mansky R, Hartmann R, Chen ZJ, Enghild JJ, Bak RO, Thomsen MK, Paludan SR.
Zhang BC, et al.
Nat Immunol. 2020 Aug;21(8):868-879. doi: 10.1038/s41590-020-0730-5. Epub 2020 Jul 20.
Nat Immunol. 2020.
PMID: 32690950
Free PMC article.
Depletion of STEEP impaired STING-driven gene expression in response to virus infection in brain tissue and in cells from patients with STING-associated diseases. Interestingly, STING gain-of-function mutants from patients interacted strongly with STEEP, leading to increas …
Depletion of STEEP impaired STING-driven gene expression in response to virus infection in brain tissue and in cells from patients with STIN …