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Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes.
Vlková V, Štěpánek I, Hrušková V, Šenigl F, Mayerová V, Šrámek M, Šímová J, Bieblová J, Indrová M, Hejhal T, Dérian N, Klatzmann D, Six A, Reiniš M. Vlková V, et al. Among authors: stepanek i. Oncotarget. 2014 Aug 30;5(16):6923-35. doi: 10.18632/oncotarget.2222. Oncotarget. 2014. PMID: 25071011 Free PMC article.
Administration of anti-CD25 mAb leads to impaired α-galactosylceramide-mediated induction of IFN-γ production in a murine model.
Rosalia RA, Štěpánek I, Polláková V, Šímová J, Bieblová J, Indrová M, Moravcová S, Přibylová H, Bontkes HJ, Bubeník J, Sparwasser T, Reiniš M. Rosalia RA, et al. Among authors: stepanek i. Immunobiology. 2013 Jun;218(6):851-9. doi: 10.1016/j.imbio.2012.10.012. Epub 2012 Oct 26. Immunobiology. 2013. PMID: 23182710
Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy.
Mikyšková R, Štěpánek I, Indrová M, Bieblová J, Šímová J, Truxová I, Moserová I, Fučíková J, Bartůňková J, Špíšek R, Reiniš M. Mikyšková R, et al. Among authors: stepanek i. Int J Oncol. 2016 Mar;48(3):953-64. doi: 10.3892/ijo.2015.3314. Epub 2015 Dec 29. Int J Oncol. 2016. PMID: 26718011 Free PMC article.
Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice.
Mikyskova R, Indrova M, Stepanek I, Kanchev I, Bieblova J, Vosahlikova S, Moserova I, Truxova I, Fucikova J, Bartunkova J, Spisek R, Sedlacek R, Reinis M. Mikyskova R, et al. Among authors: stepanek i. Oncoimmunology. 2017 Aug 24;6(12):e1362528. doi: 10.1080/2162402X.2017.1362528. eCollection 2017. Oncoimmunology. 2017. PMID: 29209567 Free PMC article.
Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods.
Zarska M, Sramek M, Novotny F, Havel F, Babelova A, Mrazkova B, Benada O, Reinis M, Stepanek I, Musilek K, Bartek J, Ursinyova M, Novak O, Dzijak R, Kuca K, Proska J, Hodny Z. Zarska M, et al. Among authors: stepanek i. Biomaterials. 2018 Feb;154:275-290. doi: 10.1016/j.biomaterials.2017.10.044. Epub 2017 Nov 1. Biomaterials. 2018. PMID: 29149721
Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations.
Kerzeli IK, Lord M, Doroszko M, Elgendy R, Chourlia A, Stepanek I, Larsson E, van Hooren L, Nelander S, Malmstrom PU, Dragomir A, Segersten U, Mangsbo SM. Kerzeli IK, et al. Among authors: stepanek i. PLoS One. 2021 Jul 7;16(7):e0253178. doi: 10.1371/journal.pone.0253178. eCollection 2021. PLoS One. 2021. PMID: 34232958 Free PMC article.
26 results