New antiviral antibiotics, cycloviracins B1 and B2. II. Structure determination

M Tsunakawa; C Kotake; T Yamasaki; T Moriyama; M Konishi; T Oki

doi:10.7164/antibiotics.45.1472

New antiviral antibiotics, cycloviracins B1 and B2. II. Structure determination

J Antibiot (Tokyo). 1992 Sep;45(9):1472-80. doi: 10.7164/antibiotics.45.1472.

Authors

M Tsunakawa¹, C Kotake, T Yamasaki, T Moriyama, M Konishi, T Oki

Affiliation

¹ Bristol-Myers Squibb Research Institute, Tokyo, Japan.

PMID: 1429233
DOI: 10.7164/antibiotics.45.1472

Abstract

The structures of novel antiviral antibiotics, cycloviracins B1 and B2 have been determined by means of chemical and spectroscopic methods including 2D NMR correlation spectroscopy. The antibiotics are unique macrocyclic diesters consisting of two D-glucoses, three 2-O-methyl-D-glucoses and two (C24 and C26) hydroxy fatty acids.

MeSH terms

Actinomycetales / chemistry*
Anti-Bacterial Agents / chemistry*
Antiviral Agents / chemistry*
Antiviral Agents / isolation & purification
Hydrolysis
Macrolides*
Magnetic Resonance Spectroscopy

Substances

Anti-Bacterial Agents
Antiviral Agents
Macrolides
cycloviracin B1
cycloviracin B2