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Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.
Roux C, Jafari SM, Shinde R, Duncan G, Cescon DW, Silvester J, Chu MF, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana MA, Mak TW, McGaha TL, Cappello P, Gorrini C. Roux C, et al. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4326-4335. doi: 10.1073/pnas.1819473116. Epub 2019 Feb 15. Proc Natl Acad Sci U S A. 2019. PMID: 30770442 Free PMC article.
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.
Kubli SP, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, Jafari SM, Snow B, Jones L, Palomero L, Thu KL, Cassetta L, Soong D, Berger T, Ramachandran P, Baniasadi SP, Duncan G, Lindzen M, Yarden Y, Herranz C, Lazaro C, Chu MF, Haight J, Tinto P, Silvester J, Cescon DW, Petit A, Pettersson S, Pollard JW, Mak TW, Pujana MA, Cappello P, Gorrini C. Kubli SP, et al. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3604-3613. doi: 10.1073/pnas.1815126116. Epub 2019 Feb 7. Proc Natl Acad Sci U S A. 2019. PMID: 30733286 Free PMC article.
Glutathione Primes T Cell Metabolism for Inflammation.
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Mak TW, et al. Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Immunity. 2017. PMID: 28423341 Free article.
Activating TCR Signaling to Thwart T-ALL.
Lemonnier F, Mak TW. Lemonnier F, et al. Cancer Discov. 2016 Sep;6(9):946-8. doi: 10.1158/2159-8290.CD-16-0789. Cancer Discov. 2016. PMID: 27587465