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MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47.
Huang W, Wang WT, Fang K, Chen ZH, Sun YM, Han C, Sun LY, Luo XQ, Chen YQ. Huang W, et al. Mol Cancer. 2018 Jan 24;17(1):12. doi: 10.1186/s12943-018-0768-2. Mol Cancer. 2018. PMID: 29368647 Free PMC article.
Functional studies showed that restoration of miR-708 expression in the T-ALL cell line is sufficient to promote phagocytosis by macrophages in the absence or presence of the anti-CD47 antibody to eradicate T-ALL cells, and inhibited tumor engraftment in vivo. Together, our findi …
Functional studies showed that restoration of miR-708 expression in the T-ALL cell line is sufficient to promote phagocytosis by macrophages …