Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation

Cancer Genet Cytogenet. 1990 Oct 15;49(2):241-8. doi: 10.1016/0165-4608(90)90148-4.

Abstract

A new T-cell line, Loucy, was established from the peripheral blood of a patient with T-cell acute lymphoblastic leukemia (T-ALL). The surface marker analysis of the cell line is OKT3+, OKT4+, THB4+, J5 +/-, OKT6-, TdT-, and HLA-DR-, indicating stage IV in T-cell lineage. Karyotype analysis revealed 45,X,5q-,t(16;20)(p12;q13). The translocation between chromosomes 16 and 20 has not been previously detected in ALL. This cell line may be of value in evaluating the role of t(16;20) in the etiology of T-ALL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Surface / analysis
  • Cell Line
  • Cells, Cultured
  • Chromosome Deletion
  • Chromosomes, Human, Pair 16*
  • Chromosomes, Human, Pair 20*
  • Chromosomes, Human, Pair 5
  • Fluorescent Antibody Technique
  • Humans
  • Karyotyping
  • Leukemia-Lymphoma, Adult T-Cell / genetics*
  • Leukemia-Lymphoma, Adult T-Cell / immunology
  • Translocation, Genetic*
  • Y Chromosome

Substances

  • Antigens, Surface