A new broad-spectrum aminoglycoside antibiotic complex, sporaricin. I. Fermentation, isolation and characterization

T Deushi; A Iwasaki; K Kamiya; T Kunieda; T Mizoguchi; M Nakayama; H Itoh; T Mori; T Oda

doi:10.7164/antibiotics.32.173

A new broad-spectrum aminoglycoside antibiotic complex, sporaricin. I. Fermentation, isolation and characterization

J Antibiot (Tokyo). 1979 Mar;32(3):173-9. doi: 10.7164/antibiotics.32.173.

Authors

T Deushi, A Iwasaki, K Kamiya, T Kunieda, T Mizoguchi, M Nakayama, H Itoh, T Mori, T Oda

PMID: 37226
DOI: 10.7164/antibiotics.32.173

Abstract

Two new aminoglycoside antibiotics, sporaricins A (C17H35N5O5) and B (C15H32N4O4) produced by a rare actinomycetales, Saccharopolyspora hirsuta subsp. kobensis have been isolated by column chromatography on a cation-exchange resin. Sporaricin A is highly active against Gram-positive and Gram-negative bacteria including aminoglycoside-resistant strains.

MeSH terms

Aminoglycosides / isolation & purification
Aminoglycosides / metabolism
Aminoglycosides / pharmacology
Anti-Bacterial Agents / biosynthesis*
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Chemical Phenomena
Chemistry, Physical
Drug Stability
Fermentation
Hydrogen-Ion Concentration
Temperature
Time Factors

Substances

Aminoglycosides
Anti-Bacterial Agents