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Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.
Chahine M, Sirois J, Marcotte P, Chen L, Kallen RG. Chahine M, et al. Biophys J. 1998 Jul;75(1):236-46. doi: 10.1016/s0006-3495(98)77510-1. Biophys J. 1998. PMID: 9649383 Free PMC article.
The tetradomain voltage-gated sodium channels from rat skeletal muscle (rSkM1) and from human heart (hH1) possess different sensitivities to the 22-amino-acid peptide toxin, mu-conotoxin GIIIA (mu-CTX). rSkM1 is sensitive (IC50 = 51.4 nM) whereas hH1 is relatively resistan …
The tetradomain voltage-gated sodium channels from rat skeletal muscle (rSkM1) and from human heart (hH1) possess different sensitivities to …
Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel.
Tang L, Chehab N, Wieland SJ, Kallen RG. Tang L, et al. J Gen Physiol. 1998 May;111(5):639-52. doi: 10.1085/jgp.111.5.639. J Gen Physiol. 1998. PMID: 9565402 Free PMC article.
M1651Q/M1652Q substitutions in the cytoplasmic loop connecting the fourth and fifth transmembrane segments of Domain 4 (S4-S5/D4) of the human heart sodium channel subtype 1 (hH1) affect the kinetics and voltage dependence of inactivation (Tang, L., R.G. ...Other substitut …
M1651Q/M1652Q substitutions in the cytoplasmic loop connecting the fourth and fifth transmembrane segments of Domain 4 (S4-S5/D4) of …
Differences in the binding sites of two site-3 sodium channel toxins.
Benzinger GR, Drum CL, Chen LQ, Kallen RG, Hanck DA, Hanck D. Benzinger GR, et al. Pflugers Arch. 1997 Nov;434(6):742-9. doi: 10.1007/s004240050460. Pflugers Arch. 1997. PMID: 9306007
Toxin/channel association rates, kon, were similar for both toxins and both parental channels. Domain 4 determined koff for ApA, while ApB dissociated from all tested chimera in a cardiac-like manner. ...We conclude that the differential component of ApA binding is control …
Toxin/channel association rates, kon, were similar for both toxins and both parental channels. Domain 4 determined koff for ApA, whil …
Effects of Tityus serrulatus scorpion toxin gamma on voltage-gated Na+ channels.
Marcotte P, Chen LQ, Kallen RG, Chahine M. Marcotte P, et al. Circ Res. 1997 Mar;80(3):363-9. doi: 10.1161/01.res.80.3.363. Circ Res. 1997. PMID: 9048656
TiTx gamma shifts the activation of a chimera (SSHH) in which domains 1 (D1) and 2 (D2) derive from rSkM1 and domain 3(D3) and 4 (D4) derive from hH1. This finding suggests that the toxin acts on the activation of rSkM1 by binding either to D1 and/or D2. ...
TiTx gamma shifts the activation of a chimera (SSHH) in which domains 1 (D1) and 2 (D2) derive from rSkM1 and domain 3(D3) and 4 (D4) …
Characterizing the mu-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations.
Chahine M, Chen LQ, Fotouhi N, Walsky R, Fry D, Santarelli V, Horn R, Kallen RG. Chahine M, et al. Recept Channels. 1995;3(3):161-74. Recept Channels. 1995. PMID: 8821790
The blocking of Na+ currents of rSkM1 expressed in Xenopus oocytes by mu-CTX analogs in which negative charge had been removed by Asn substitution for Asp or positive charge had been decreased by Gln substitution for Arg or Lys was studied; the mu-CTX analogs exhibited decreased …
The blocking of Na+ currents of rSkM1 expressed in Xenopus oocytes by mu-CTX analogs in which negative charge had been removed by Asn substi …