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Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis.
J Neuroinflammation. 2023 Jan 6;20(1):5. doi: 10.1186/s12974-022-02677-7.
J Neuroinflammation. 2023.
PMID: 36609298
Free PMC article.
BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.
Quezada E, Cappelli C, Diaz I, Jury N, Wightman N, Brown RH Jr, Montecino M, van Zundert B.
Quezada E, et al.
Clin Epigenetics. 2021 Mar 16;13(1):56. doi: 10.1186/s13148-021-01039-z.
Clin Epigenetics. 2021.
PMID: 33726839
Free PMC article.
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