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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.
Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. Panicker N, et al. Among authors: jhaldiyal a. Neuron. 2022 Aug 3;110(15):2422-2437.e9. doi: 10.1016/j.neuron.2022.05.009. Epub 2022 Jun 1. Neuron. 2022. PMID: 35654037 Free PMC article.
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease.
Khan MR, Yin X, Kang SU, Mitra J, Wang H, Ryu T, Brahmachari S, Karuppagounder SS, Kimura Y, Jhaldiyal A, Kim HH, Gu H, Chen R, Redding-Ochoa J, Troncoso J, Na CH, Ha T, Dawson VL, Dawson TM. Khan MR, et al. Among authors: jhaldiyal a. Sci Transl Med. 2023 Nov 29;15(724):eadd0499. doi: 10.1126/scitranslmed.add0499. Epub 2023 Nov 29. Sci Transl Med. 2023. PMID: 38019930
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease.
Park JS, Kam TI, Lee S, Park H, Oh Y, Kwon SH, Song JJ, Kim D, Kim H, Jhaldiyal A, Na DH, Lee KC, Park EJ, Pomper MG, Pletnikova O, Troncoso JC, Ko HS, Dawson VL, Dawson TM, Lee S. Park JS, et al. Among authors: jhaldiyal a. Acta Neuropathol Commun. 2021 Apr 26;9(1):78. doi: 10.1186/s40478-021-01180-z. Acta Neuropathol Commun. 2021. PMID: 33902708 Free PMC article.
Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons.
Kumar M, Acevedo-Cintrón J, Jhaldiyal A, Wang H, Andrabi SA, Eacker S, Karuppagounder SS, Brahmachari S, Chen R, Kim H, Ko HS, Dawson VL, Dawson TM. Kumar M, et al. Among authors: jhaldiyal a. Stem Cell Reports. 2020 Sep 8;15(3):629-645. doi: 10.1016/j.stemcr.2020.07.013. Epub 2020 Aug 13. Stem Cell Reports. 2020. PMID: 32795422 Free PMC article.
Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis.
Kim JW, Yin X, Jhaldiyal A, Khan MR, Martin I, Xie Z, Perez-Rosello T, Kumar M, Abalde-Atristain L, Xu J, Chen L, Eacker SM, Surmeier DJ, Ingolia NT, Dawson TM, Dawson VL. Kim JW, et al. Among authors: jhaldiyal a. Cell Stem Cell. 2020 Oct 1;27(4):633-645.e7. doi: 10.1016/j.stem.2020.08.002. Epub 2020 Aug 25. Cell Stem Cell. 2020. PMID: 32846140 Free PMC article.
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.
Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL. Karuppagounder SS, et al. Among authors: jhaldiyal a. J Chem Neuroanat. 2016 Oct;76(Pt B):90-97. doi: 10.1016/j.jchemneu.2016.01.007. Epub 2016 Jan 22. J Chem Neuroanat. 2016. PMID: 26808467 Free PMC article.