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Mitochondria-containing extracellular vesicles (EV) reduce mouse brain infarct sizes and EV/HSP27 protect ischemic brain endothelial cultures.
Dave KM, Stolz DB, Venna VR, Quaicoe VA, Maniskas ME, Reynolds MJ, Babidhan R, Dobbins DX, Farinelli MN, Sullivan A, Bhatia TN, Yankello H, Reddy R, Bae Y, Leak RK, Shiva SS, McCullough LD, Manickam DS. Dave KM, et al. Among authors: sullivan a. J Control Release. 2023 Feb;354:368-393. doi: 10.1016/j.jconrel.2023.01.025. Epub 2023 Jan 18. J Control Release. 2023. PMID: 36642252 Free PMC article.
Engineering Extracellular Vesicles to Modulate Their Innate Mitochondrial Load.
Dave KM, Dobbins DX, Farinelli MN, Sullivan A, Milosevic J, Stolz DB, Kim J, Zheng S, Manickam DS. Dave KM, et al. Among authors: sullivan a. Cell Mol Bioeng. 2022 Sep 19;15(5):367-389. doi: 10.1007/s12195-022-00738-8. eCollection 2022 Oct. Cell Mol Bioeng. 2022. PMID: 36444353 Free PMC article.