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PI3K/Akt-mediated regulation of p53 in cancer.
Abraham AG, O'Neill E. Abraham AG, et al. Biochem Soc Trans. 2014 Aug;42(4):798-803. doi: 10.1042/BST20140070. Biochem Soc Trans. 2014. PMID: 25109960 Review.
AKT regulates NPM dependent ARF localization and p53mut stability in tumors.
Hamilton G, Abraham AG, Morton J, Sampson O, Pefani DE, Khoronenkova S, Grawenda A, Papaspyropoulos A, Jamieson N, McKay C, Sansom O, Dianov GL, O'Neill E. Hamilton G, et al. Among authors: abraham ag. Oncotarget. 2014 Aug 15;5(15):6142-67. doi: 10.18632/oncotarget.2178. Oncotarget. 2014. PMID: 25071014 Free PMC article.
TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.
Eyres M, Lanfredini S, Xu H, Burns A, Blake A, Willenbrock F, Goldin R, Hughes D, Hughes S, Thapa A, Vavoulis D, Hubert A, D'Costa Z, Sabbagh A, Abraham AG, Blancher C, Jones S, Verrill C, Silva M, Soonawalla Z, Maughan T, Schuh A, Mukherjee S, O'Neill E. Eyres M, et al. Among authors: abraham ag. Gastroenterology. 2021 Aug;161(2):653-668.e16. doi: 10.1053/j.gastro.2021.04.044. Epub 2021 Apr 27. Gastroenterology. 2021. PMID: 33915173
ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer.
Wilson JM, Fokas E, Dutton SJ, Patel N, Hawkins MA, Eccles C, Chu KY, Durrant L, Abraham AG, Partridge M, Woodward M, O'Neill E, Maughan T, McKenna WG, Mukherjee S, Brunner TB. Wilson JM, et al. Among authors: abraham ag. Radiother Oncol. 2016 May;119(2):306-11. doi: 10.1016/j.radonc.2016.03.021. Epub 2016 Apr 23. Radiother Oncol. 2016. PMID: 27117177 Free PMC article. Clinical Trial.
Menin determines K-RAS proliferative outputs in endocrine cells.
Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS. Chamberlain CE, et al. Among authors: abraham ag. J Clin Invest. 2014 Sep;124(9):4093-101. doi: 10.1172/JCI69004. Epub 2014 Aug 18. J Clin Invest. 2014. PMID: 25133424 Free PMC article.
Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT.
Leszczynska KB, Foskolou IP, Abraham AG, Anbalagan S, Tellier C, Haider S, Span PN, O'Neill EE, Buffa FM, Hammond EM. Leszczynska KB, et al. Among authors: abraham ag. J Clin Invest. 2015 Jun;125(6):2385-98. doi: 10.1172/JCI80402. Epub 2015 May 11. J Clin Invest. 2015. PMID: 25961455 Free PMC article.
Circulating biomarkers and outcomes from a randomised phase 2 trial of gemcitabine versus capecitabine-based chemoradiotherapy for pancreatic cancer.
Willenbrock F, Cox CM, Parkes EE, Wilhelm-Benartzi CS, Abraham AG, Owens R, Sabbagh A, Jones CM, Hughes DLI, Maughan T, Hurt CN, O'Neill EE, Mukherjee S. Willenbrock F, et al. Among authors: abraham ag. Br J Cancer. 2021 Feb;124(3):581-586. doi: 10.1038/s41416-020-01120-z. Epub 2020 Oct 26. Br J Cancer. 2021. PMID: 33100327 Free PMC article. Clinical Trial.
229 results