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Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase.
Peng H, Xie W, Kim DI, Zalkow LH, Powis G, Otterness DM, Abraham RT. Peng H, et al. Among authors: abraham rt. Bioorg Med Chem. 2000 Feb;8(2):299-306. doi: 10.1016/s0968-0896(99)00284-9. Bioorg Med Chem. 2000. PMID: 10722152
Their potency ranged from 1.1 to > 100 microM; the best ones compare very favorably with that of the novel cyano-containing 5,6-seco-cholesteryl acid 1 (IC50=2.2microM) reported by us recently (Peng, H.; Zalkow, L. H.; Abraham, R. T.; Powis, G. J. Med. Chem. 1998 …
Their potency ranged from 1.1 to > 100 microM; the best ones compare very favorably with that of the novel cyano-containing 5,6-seco-chol …
The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.
Ihle NT, Paine-Murrieta G, Berggren MI, Baker A, Tate WR, Wipf P, Abraham RT, Kirkpatrick DL, Powis G. Ihle NT, et al. Among authors: abraham rt. Mol Cancer Ther. 2005 Sep;4(9):1349-57. doi: 10.1158/1535-7163.MCT-05-0149. Mol Cancer Ther. 2005. PMID: 16170026 Free PMC article.
Targeting the mTOR signaling network in cancer.
Chiang GG, Abraham RT. Chiang GG, et al. Trends Mol Med. 2007 Oct;13(10):433-42. doi: 10.1016/j.molmed.2007.08.001. Epub 2007 Oct 1. Trends Mol Med. 2007. PMID: 17905659 Review.
1,382 results