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A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis.
Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ. Neal MD, et al. Among authors: afrazi a. J Immunol. 2013 Apr 1;190(7):3541-51. doi: 10.4049/jimmunol.1202264. Epub 2013 Mar 1. J Immunol. 2013. PMID: 23455503 Free PMC article.
Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms.
Kaczorowski DJ, Afrazi A, Scott MJ, Kwak JH, Gill R, Edmonds RD, Liu Y, Fan J, Billiar TR. Kaczorowski DJ, et al. Among authors: afrazi a. J Leukoc Biol. 2010 Oct;88(4):609-18. doi: 10.1189/jlb.0809588. Epub 2010 Apr 22. J Leukoc Biol. 2010. PMID: 20413727 Free PMC article.
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.
Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ. Neal MD, et al. Among authors: afrazi a. J Biol Chem. 2012 Oct 26;287(44):37296-308. doi: 10.1074/jbc.M112.375881. Epub 2012 Sep 6. J Biol Chem. 2012. PMID: 22955282 Free PMC article.
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling.
Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ. Yazji I, et al. Among authors: afrazi a. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9451-6. doi: 10.1073/pnas.1219997110. Epub 2013 May 6. Proc Natl Acad Sci U S A. 2013. PMID: 23650378 Free PMC article.
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.
Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ. Sodhi CP, et al. Among authors: afrazi a. Gastroenterology. 2012 Sep;143(3):708-718.e5. doi: 10.1053/j.gastro.2012.05.053. Epub 2012 Jul 13. Gastroenterology. 2012. PMID: 22796522 Free PMC article.
Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.
Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ. Afrazi A, et al. J Biol Chem. 2014 Apr 4;289(14):9584-99. doi: 10.1074/jbc.M113.526517. Epub 2014 Feb 11. J Biol Chem. 2014. PMID: 24519940 Free PMC article.
Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium.
Richardson WM, Sodhi CP, Russo A, Siggers RH, Afrazi A, Gribar SC, Neal MD, Dai S, Prindle T Jr, Branca M, Ma C, Ozolek J, Hackam DJ. Richardson WM, et al. Among authors: afrazi a. Gastroenterology. 2010 Sep;139(3):904-17, 917.e1-6. doi: 10.1053/j.gastro.2010.05.038. Epub 2010 May 24. Gastroenterology. 2010. PMID: 20580721 Free PMC article.
28 results