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Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung.
Moreo E, Jarit-Cabanillas A, Robles-Vera I, Uranga S, Guerrero C, Gómez AB, Mata-Martínez P, Minute L, Araujo-Voces M, Felgueres MJ, Esteso G, Uranga-Murillo I, Arias M, Pardo J, Martín C, Valés-Gómez M, Del Fresno C, Sancho D, Aguiló N. Moreo E, et al. Among authors: aguilo n. Nat Commun. 2023 Oct 4;14(1):6090. doi: 10.1038/s41467-023-41768-8. Nat Commun. 2023. PMID: 37794033 Free PMC article.
Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis.
Mata E, Tarancon R, Guerrero C, Moreo E, Moreau F, Uranga S, Gomez AB, Marinova D, Domenech M, Gonzalez-Camacho F, Monzon M, Badiola J, Dominguez-Andres J, Yuste J, Anel A, Peixoto A, Martin C, Aguilo N. Mata E, et al. Among authors: aguilo n. Sci Immunol. 2021 Sep 24;6(63):eabc2934. doi: 10.1126/sciimmunol.abc2934. Epub 2021 Sep 24. Sci Immunol. 2021. PMID: 34559551
BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro.
Esteso G, Felgueres MJ, García-Jiménez ÁF, Reyburn-Valés C, Benguría A, Vázquez E, Reyburn HT, Aguiló N, Martín C, Puentes E, Murillo I, Rodríguez E, Valés-Gómez M. Esteso G, et al. Among authors: aguilo n. Oncoimmunology. 2022 Dec 22;12(1):2160094. doi: 10.1080/2162402X.2022.2160094. eCollection 2023. Oncoimmunology. 2022. PMID: 36567803 Free PMC article.
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