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Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation.
J Biol Chem. 2020 Mar 6;295(10):3330-3346. doi: 10.1074/jbc.RA120.012533. Epub 2020 Jan 23.
J Biol Chem. 2020.
PMID: 31974165
Free PMC article.
Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.
Ford BE, Chachra SS, Alshawi A, Brennan A, Harnor S, Cano C, Baker DJ, Smith DM, Fairclough RJ, Agius L.
Ford BE, et al. Among authors: alshawi a.
Diabetes Obes Metab. 2020 Nov;22(11):1985-1994. doi: 10.1111/dom.14111. Epub 2020 Jul 7.
Diabetes Obes Metab. 2020.
PMID: 32519798
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Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.
Alshawi A, Agius L.
Alshawi A, et al.
J Biol Chem. 2019 Feb 22;294(8):2839-2853. doi: 10.1074/jbc.RA118.006670. Epub 2018 Dec 27.
J Biol Chem. 2019.
PMID: 30591586
Free PMC article.
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Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.
Al-Oanzi ZH, Fountana S, Moonira T, Tudhope SJ, Petrie JL, Alshawi A, Patman G, Arden C, Reeves HL, Agius L.
Al-Oanzi ZH, et al. Among authors: alshawi a.
Diabetes Obes Metab. 2017 Aug;19(8):1078-1087. doi: 10.1111/dom.12910. Epub 2017 Apr 10.
Diabetes Obes Metab. 2017.
PMID: 28206714
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