Aihara H - Search Results

1

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues.

Kvach MV, Barzak FM, Harjes S, Schares HAM, Jameson GB, Ayoub AM, Moorthy R, Aihara H, Harris RS, Filichev VV, Harki DA, Harjes E. Kvach MV, et al. Among authors: aihara h. Biochemistry. 2019 Feb 5;58(5):391-400. doi: 10.1021/acs.biochem.8b00858. Epub 2018 Nov 28. Biochemistry. 2019. PMID: 30418757 Free PMC article.

2

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.

Shi K, Carpenter MA, Kurahashi K, Harris RS, Aihara H. Shi K, et al. Among authors: aihara h. J Biol Chem. 2015 Nov 20;290(47):28120-28130. doi: 10.1074/jbc.M115.679951. Epub 2015 Sep 28. J Biol Chem. 2015. PMID: 26416889 Free PMC article.

3

1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure.

Shaban NM, Shi K, Li M, Aihara H, Harris RS. Shaban NM, et al. Among authors: aihara h. J Mol Biol. 2016 Jun 5;428(11):2307-2316. doi: 10.1016/j.jmb.2016.04.026. Epub 2016 Apr 30. J Mol Biol. 2016. PMID: 27139641 Free PMC article.

4

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Demir Ö, Amaro RE, Harki DA, Harris RS, Aihara H. Shi K, et al. Among authors: aihara h. Nat Struct Mol Biol. 2017 Feb;24(2):131-139. doi: 10.1038/nsmb.3344. Epub 2016 Dec 19. Nat Struct Mol Biol. 2017. PMID: 27991903 Free PMC article.

5

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.

Shi K, Demir Ö, Carpenter MA, Wagner J, Kurahashi K, Harris RS, Amaro RE, Aihara H. Shi K, et al. Among authors: aihara h. Sci Rep. 2017 Dec 12;7(1):17415. doi: 10.1038/s41598-017-17694-3. Sci Rep. 2017. PMID: 29234087 Free PMC article.

6

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.

Shaban NM, Shi K, Lauer KV, Carpenter MA, Richards CM, Salamango D, Wang J, Lopresti MW, Banerjee S, Levin-Klein R, Brown WL, Aihara H, Harris RS. Shaban NM, et al. Among authors: aihara h. Mol Cell. 2018 Jan 4;69(1):75-86.e9. doi: 10.1016/j.molcel.2017.12.010. Epub 2017 Dec 28. Mol Cell. 2018. PMID: 29290613 Free PMC article.

7

Determinants of Oligonucleotide Selectivity of APOBEC3B.

Wagner JR, Demir Ö, Carpenter MA, Aihara H, Harki DA, Harris RS, Amaro RE. Wagner JR, et al. Among authors: aihara h. J Chem Inf Model. 2019 May 28;59(5):2264-2273. doi: 10.1021/acs.jcim.8b00427. Epub 2018 Sep 10. J Chem Inf Model. 2019. PMID: 30130104 Free PMC article.

8

The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H.

Wang J, Becker JT, Shi K, Lauer KV, Salamango DJ, Aihara H, Shaban NM, Harris RS. Wang J, et al. Among authors: aihara h. J Mol Biol. 2019 Dec 6;431(24):5019-5031. doi: 10.1016/j.jmb.2019.09.014. Epub 2019 Oct 16. J Mol Biol. 2019. PMID: 31628948 Free PMC article.

9

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B.

Shi K, Demir Ö, Carpenter MA, Banerjee S, Harki DA, Amaro RE, Harris RS, Aihara H. Shi K, et al. Among authors: aihara h. FASEB Bioadv. 2019 Dec 24;2(1):49-58. doi: 10.1096/fba.2019-00068. eCollection 2020 Jan. FASEB Bioadv. 2019. PMID: 32123856 Free PMC article.

10

Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement*.

Cui H, Divakaran A, Pandey AK, Johnson JA, Zahid H, Hoell ZJ, Ellingson MO, Shi K, Aihara H, Harki DA, Pomerantz WCK. Cui H, et al. Among authors: aihara h. Angew Chem Int Ed Engl. 2021 Jan 18;60(3):1220-1226. doi: 10.1002/anie.202008625. Epub 2020 Nov 18. Angew Chem Int Ed Engl. 2021. PMID: 32975004 Free PMC article.

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