Ainslie GR - Search Results

1

In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells.

Vogel KR, Ainslie GR, Jansen EE, Salomons GS, Roullet JB, Gibson KM. Vogel KR, et al. Among authors: ainslie gr. PLoS One. 2017 Oct 20;12(10):e0186919. doi: 10.1371/journal.pone.0186919. eCollection 2017. PLoS One. 2017. PMID: 29053743 Free PMC article.

2

Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism.

Malaspina P, Roullet JB, Pearl PL, Ainslie GR, Vogel KR, Gibson KM. Malaspina P, et al. Among authors: ainslie gr. Neurochem Int. 2016 Oct;99:72-84. doi: 10.1016/j.neuint.2016.06.009. Epub 2016 Jun 14. Neurochem Int. 2016. PMID: 27311541 Free PMC article. Review.

3

Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.

Vogel KR, Ainslie GR, Jansen EE, Salomons GS, Gibson KM. Vogel KR, et al. Among authors: ainslie gr. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):33-42. doi: 10.1016/j.bbadis.2016.10.009. Epub 2016 Oct 17. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27760377 Free PMC article.

4

Targeted screening of succinic semialdehyde dehydrogenase deficiency (SSADHD) employing an enzymatic assay for γ-hydroxybutyric acid (GHB) in biofluids.

Wernli C, Finochiaro S, Volken C, Andresen-Streichert H, Buettler A, Gygax D, Salomons GS, Jansen EE, Ainslie GR, Vogel KR, Gibson KM. Wernli C, et al. Among authors: ainslie gr. Mol Genet Metab Rep. 2016 Aug 17;11:81-89. doi: 10.1016/j.ymgmr.2016.07.009. eCollection 2017 Jun. Mol Genet Metab Rep. 2016. PMID: 28649510 Free PMC article.

5

Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder.

Vogel KR, Ainslie GR, McConnell A, Roullet JB, Gibson KM. Vogel KR, et al. Among authors: ainslie gr. Toxicol In Vitro. 2018 Feb;46:203-212. doi: 10.1016/j.tiv.2017.10.015. Epub 2017 Oct 12. Toxicol In Vitro. 2018. PMID: 29031482 Free PMC article.

6

mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.

Vogel KR, Ainslie GR, Gibson KM. Vogel KR, et al. Among authors: ainslie gr. J Inherit Metab Dis. 2016 Nov;39(6):877-886. doi: 10.1007/s10545-016-9959-4. Epub 2016 Aug 12. J Inherit Metab Dis. 2016. PMID: 27518770 Free PMC article.

7

Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies.

Vogel KR, Ainslie GR, Walters DC, McConnell A, Dhamne SC, Rotenberg A, Roullet JB, Gibson KM. Vogel KR, et al. Among authors: ainslie gr. J Inherit Metab Dis. 2018 Jul;41(4):699-708. doi: 10.1007/s10545-018-0153-8. Epub 2018 Feb 19. J Inherit Metab Dis. 2018. PMID: 29460030 Free PMC article. Review.

8

In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding.

Vogel KR, Ainslie GR, Roullet JB, McConnell A, Gibson KM. Vogel KR, et al. Among authors: ainslie gr. Toxicol In Vitro. 2017 Apr;40:196-202. doi: 10.1016/j.tiv.2017.01.013. Epub 2017 Jan 22. Toxicol In Vitro. 2017. PMID: 28119166

9

Gamma-Hydroxybutyrate (GHB) Content in Hair Samples Correlates Negatively with Age in Succinic Semialdehyde Dehydrogenase Deficiency.

Johansen SS, Wang X, Sejer Pedersen D, Pearl PL, Roullet JB, Ainslie GR, Vogel KR, Gibson KM. Johansen SS, et al. Among authors: ainslie gr. JIMD Rep. 2017;36:93-98. doi: 10.1007/8904_2017_3. Epub 2017 Feb 18. JIMD Rep. 2017. PMID: 28213850 Free PMC article.

10

Torin 1 partially corrects vigabatrin-induced mitochondrial increase in mouse.

Vogel KR, Ainslie GR, Jansen EE, Salomons GS, Gibson KM. Vogel KR, et al. Among authors: ainslie gr. Ann Clin Transl Neurol. 2015 Jun;2(6):699-706. doi: 10.1002/acn3.200. Epub 2015 Apr 17. Ann Clin Transl Neurol. 2015. PMID: 26125044 Free PMC article.

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