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Page 1
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J Med Chem. 2020 Mar 26;63(6):3215-3226. doi: 10.1021/acs.jmedchem.9b01979. Epub 2020 Mar 16.
J Med Chem. 2020.
PMID: 32142284
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
Tanaka Y, Kurasawa O, Yokota A, Klein MG, Saito B, Matsumoto S, Okaniwa M, Ambrus-Aikelin G, Uchiyama N, Morishita D, Kimura H, Imamura S.
Tanaka Y, et al. Among authors: yokota a.
ACS Med Chem Lett. 2020 Jul 30;11(8):1645-1652. doi: 10.1021/acsmedchemlett.0c00331. eCollection 2020 Aug 13.
ACS Med Chem Lett. 2020.
PMID: 34345355
Free PMC article.
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TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Kunugi A, Tanaka M, Suzuki A, Tajima Y, Suzuki N, Suzuki M, Nakamura S, Kuno H, Yokota A, Sogabe S, Kosugi Y, Awasaki Y, Kaku T, Kimura H.
Kunugi A, et al. Among authors: yokota a.
Neuropsychopharmacology. 2019 Apr;44(5):961-970. doi: 10.1038/s41386-018-0213-7. Epub 2018 Sep 12.
Neuropsychopharmacology. 2019.
PMID: 30209408
Free PMC article.
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Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Hirayama T, Okaniwa M, Banno H, Kakei H, Ohashi A, Ohori M, Nambu T, Iwai K, Kawamoto T, Yokota A, Miyamoto M, Ishikawa T.
Hirayama T, et al. Among authors: yokota a.
Bioorg Med Chem Lett. 2016 Sep 1;26(17):4296-300. doi: 10.1016/j.bmcl.2016.07.038. Epub 2016 Jul 19.
Bioorg Med Chem Lett. 2016.
PMID: 27476141
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Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Hirayama T, Okaniwa M, Imada T, Ohashi A, Ohori M, Iwai K, Mori K, Kawamoto T, Yokota A, Tanaka T, Ishikawa T.
Hirayama T, et al. Among authors: yokota a.
Bioorg Med Chem. 2013 Sep 1;21(17):5488-502. doi: 10.1016/j.bmc.2013.05.067. Epub 2013 Jun 11.
Bioorg Med Chem. 2013.
PMID: 23816042
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Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.
Hirayama T, Okaniwa M, Banno H, Kakei H, Ohashi A, Iwai K, Ohori M, Mori K, Gotou M, Kawamoto T, Yokota A, Ishikawa T.
Hirayama T, et al. Among authors: yokota a.
J Med Chem. 2015 Oct 22;58(20):8036-53. doi: 10.1021/acs.jmedchem.5b00836. Epub 2015 Oct 1.
J Med Chem. 2015.
PMID: 26372373
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