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Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties.
McCubrey JA, Meher AK, Akula SM, Abrams SL, Steelman LS, LaHair MM, Franklin RA, Martelli AM, Ratti S, Cocco L, Barbaro F, Duda P, Gizak A. McCubrey JA, et al. Among authors: akula sm. Aging (Albany NY). 2022 Apr 27;14(8):3365-3386. doi: 10.18632/aging.204038. Epub 2022 Apr 27. Aging (Albany NY). 2022. PMID: 35477123 Free PMC article.
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