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Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors.
Taddeo A, Khodadadi L, Voigt C, Mumtaz IM, Cheng Q, Moser K, Alexander T, Manz RA, Radbruch A, Hiepe F, Hoyer BF. Taddeo A, et al. Among authors: alexander t. Arthritis Res Ther. 2015 Mar 2;17(1):39. doi: 10.1186/s13075-015-0551-3. Arthritis Res Ther. 2015. PMID: 25889236 Free PMC article.
Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system.
Alexander T, Thiel A, Rosen O, Massenkeil G, Sattler A, Kohler S, Mei H, Radtke H, Gromnica-Ihle E, Burmester GR, Arnold R, Radbruch A, Hiepe F. Alexander T, et al. Blood. 2009 Jan 1;113(1):214-23. doi: 10.1182/blood-2008-07-168286. Epub 2008 Sep 29. Blood. 2009. PMID: 18824594 Free article. Clinical Trial.
Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-γ memory in human CD4(+) T lymphocytes.
Dong J, Chang HD, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A. Dong J, et al. Among authors: alexander t. Eur J Immunol. 2013 Mar;43(3):793-804. doi: 10.1002/eji.201242858. Eur J Immunol. 2013. PMID: 23255246 Free article.
Development and resolution of secondary autoimmunity after autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: competition of plasma cells for survival niches?
Alexander T, Schneider S, Hoyer B, Cheng Q, Thiel A, Ziemer S, Burmester GR, Arnold R, Radbruch A, Hiepe F. Alexander T, et al. Ann Rheum Dis. 2013 Jun;72(6):1102-4. doi: 10.1136/annrheumdis-2012-202729. Epub 2013 Jan 29. Ann Rheum Dis. 2013. PMID: 23361083 No abstract available.
999 results