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Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice.
Chen SY, Beretta M, Olzomer EM, Shah DP, Wong DYH, Alexopoulos SJ, Aleksovska I, Salamoun JM, Garcia CJ, Cochran BJ, Rye KA, Smith GC, Byrne FL, Morris MJ, Santos WL, Cantley J, Hoehn KL. Chen SY, et al. Among authors: alexopoulos sj. Mol Metab. 2023 Mar;69:101684. doi: 10.1016/j.molmet.2023.101684. Epub 2023 Jan 31. Mol Metab. 2023. PMID: 36731653 Free PMC article.
Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.
Byrne FL, Olzomer EM, Marriott GR, Quek LE, Katen A, Su J, Nelson ME, Hart-Smith G, Larance M, Sebesfi VF, Cuff J, Martyn GE, Childress E, Alexopoulos SJ, Poon IK, Faux MC, Burgess AW, Reid G, McCarroll JA, Santos WL, Quinlan KG, Turner N, Fazakerley DJ, Kumar N, Hoehn KL. Byrne FL, et al. Among authors: alexopoulos sj. Redox Biol. 2020 Jan;28:101374. doi: 10.1016/j.redox.2019.101374. Epub 2019 Nov 5. Redox Biol. 2020. PMID: 31743887 Free PMC article.
[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis.
Childress ES, Salamoun JM, Hargett SR, Alexopoulos SJ, Chen SY, Shah DP, Santiago-Rivera J, Garcia CJ, Dai Y, Tucker SP, Hoehn KL, Santos WL. Childress ES, et al. Among authors: alexopoulos sj. J Med Chem. 2020 Mar 12;63(5):2511-2526. doi: 10.1021/acs.jmedchem.9b01440. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32017849 Free PMC article.
6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis.
Salamoun JM, Garcia CJ, Hargett SR, Murray JH, Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Tucker SP, Hoehn KL, Santos WL. Salamoun JM, et al. Among authors: alexopoulos sj. J Med Chem. 2020 Jun 11;63(11):6203-6224. doi: 10.1021/acs.jmedchem.0c00542. Epub 2020 May 27. J Med Chem. 2020. PMID: 32392051 Free PMC article.
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL. Alexopoulos SJ, et al. Nat Commun. 2020 May 14;11(1):2397. doi: 10.1038/s41467-020-16298-2. Nat Commun. 2020. PMID: 32409697 Free PMC article.
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP. Axelrod CL, et al. Among authors: alexopoulos sj. EMBO Mol Med. 2020 Jul 7;12(7):e12088. doi: 10.15252/emmm.202012088. Epub 2020 Jun 10. EMBO Mol Med. 2020. PMID: 32519812 Free PMC article.
Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3).
Knights AJ, Vohralik EJ, Houweling PJ, Stout ES, Norton LJ, Alexopoulos SJ, Yik JJ, Mat Jusoh H, Olzomer EM, Bell-Anderson KS, North KN, Hoehn KL, Crossley M, Quinlan KGR. Knights AJ, et al. Among authors: alexopoulos sj. Nat Commun. 2020 Jun 10;11(1):2922. doi: 10.1038/s41467-020-16758-9. Nat Commun. 2020. PMID: 32523103 Free PMC article.
Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake.
Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Hargett SR, Childress ES, Salamoun JM, Aleksovska I, Roseblade A, Cranfield C, Rawling T, Quinlan KGR, Morris MJ, Tucker SP, Santos WL, Hoehn KL. Chen SY, et al. Among authors: alexopoulos sj. Metabolism. 2021 Apr;117:154724. doi: 10.1016/j.metabol.2021.154724. Epub 2021 Feb 4. Metabolism. 2021. PMID: 33548253
15 results