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Page 1
CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies.
Wang D, Prager BC, Gimple RC, Aguilar B, Alizadeh D, Tang H, Lv D, Starr R, Brito A, Wu Q, Kim LJY, Qiu Z, Lin P, Lorenzini MH, Badie B, Forman SJ, Xie Q, Brown CE, Rich JN. Wang D, et al. Among authors: brito a. Cancer Discov. 2021 May;11(5):1192-1211. doi: 10.1158/2159-8290.CD-20-1243. Epub 2020 Dec 16. Cancer Discov. 2021. PMID: 33328215 Free PMC article.
Inclusion of 4-1BB Costimulation Enhances Selectivity and Functionality of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells.
Starr R, Aguilar B, Gumber D, Maker M, Huard S, Wang D, Chang WC, Brito A, Chiu V, Ostberg JR, Badie B, Forman SJ, Alizadeh D, Wang LD, Brown CE. Starr R, et al. Among authors: brito a. Cancer Res Commun. 2023 Jan 17;3(1):66-79. doi: 10.1158/2767-9764.CRC-22-0185. eCollection 2023 Jan. Cancer Res Commun. 2023. PMID: 36968221 Free PMC article.
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity.
Wang D, Aguilar B, Starr R, Alizadeh D, Brito A, Sarkissian A, Ostberg JR, Forman SJ, Brown CE. Wang D, et al. Among authors: brito a. JCI Insight. 2018 May 17;3(10):e99048. doi: 10.1172/jci.insight.99048. eCollection 2018 May 17. JCI Insight. 2018. PMID: 29769444 Free PMC article.
Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma.
Wang D, Starr R, Chang WC, Aguilar B, Alizadeh D, Wright SL, Yang X, Brito A, Sarkissian A, Ostberg JR, Li L, Shi Y, Gutova M, Aboody K, Badie B, Forman SJ, Barish ME, Brown CE. Wang D, et al. Among authors: brito a. Sci Transl Med. 2020 Mar 4;12(533):eaaw2672. doi: 10.1126/scitranslmed.aaw2672. Sci Transl Med. 2020. PMID: 32132216 Free PMC article.
The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma.
Wang X, Huynh C, Urak R, Weng L, Walter M, Lim L, Vyas V, Chang WC, Aguilar B, Brito A, Sarkissian A, Bandara NA, Yang L, Wang J, Wu X, Zhang J, Priceman SJ, Qin H, Kwak LW, Budde LE, Thomas SH, Clark MC, Popplewell L, Siddiqi T, Brown CE, Forman SJ. Wang X, et al. Among authors: brito a. Cancer Immunol Res. 2021 Jan;9(1):75-88. doi: 10.1158/2326-6066.CIR-20-0236. Epub 2020 Oct 22. Cancer Immunol Res. 2021. PMID: 33093217 Free PMC article.