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AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, Graef IA, Alhamadsheh MM. Penchala SC, et al. Among authors: alhamadsheh mm. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. doi: 10.1073/pnas.1300761110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716704 Free PMC article.
A biomimetic approach for enhancing the in vivo half-life of peptides.
Penchala SC, Miller MR, Pal A, Dong J, Madadi NR, Xie J, Joo H, Tsai J, Batoon P, Samoshin V, Franz A, Cox T, Miles J, Chan WK, Park MS, Alhamadsheh MM. Penchala SC, et al. Among authors: alhamadsheh mm. Nat Chem Biol. 2015 Oct;11(10):793-8. doi: 10.1038/nchembio.1907. Epub 2015 Sep 7. Nat Chem Biol. 2015. PMID: 26344696 Free PMC article.
Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis.
Miller M, Pal A, Albusairi W, Joo H, Pappas B, Haque Tuhin MT, Liang D, Jampala R, Liu F, Khan J, Faaij M, Park M, Chan W, Graef I, Zamboni R, Kumar N, Fox J, Sinha U, Alhamadsheh M. Miller M, et al. J Med Chem. 2018 Sep 13;61(17):7862-7876. doi: 10.1021/acs.jmedchem.8b00817. Epub 2018 Aug 22. J Med Chem. 2018. PMID: 30133284 Free PMC article.
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.
Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS. Eustáquio AS, et al. Among authors: alhamadsheh mm. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12295-300. doi: 10.1073/pnas.0901237106. Epub 2009 Jul 9. Proc Natl Acad Sci U S A. 2009. PMID: 19590008 Free PMC article.
24 results