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Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.
Seregin SS, Rastall DP, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal RP, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A. Seregin SS, et al. Among authors: amalfitano a. Autoimmunity. 2013 Dec;46(8):497-508. doi: 10.3109/08916934.2013.819855. Epub 2013 Sep 13. Autoimmunity. 2013. PMID: 24028501 Free PMC article.
Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.
Aldhamen YA, Pepelyayeva Y, Rastall DP, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A. Aldhamen YA, et al. Among authors: amalfitano a. J Innate Immun. 2015;7(3):275-89. doi: 10.1159/000368899. Epub 2015 Jan 14. J Innate Immun. 2015. PMID: 25591727 Free PMC article.
Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.
Rastall DPW, Alyaquob FS, O'Connell P, Pepelyayeva Y, Peters D, Godbehere-Roosa S, Pereira-Hicks C, Aldhamen YA, Amalfitano A. Rastall DPW, et al. Among authors: amalfitano a. Int Immunol. 2017 Jun 1;29(6):277-289. doi: 10.1093/intimm/dxx035. Int Immunol. 2017. PMID: 28814066 Free PMC article.
Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.
Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E. Evnouchidou I, et al. Among authors: amalfitano a. J Immunol. 2011 Feb 15;186(4):1909-13. doi: 10.4049/jimmunol.1003337. Epub 2011 Jan 17. J Immunol. 2011. PMID: 21242517 Free PMC article.
136 results