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Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer.
Backman M, Strell C, Lindberg A, Mattsson JSM, Elfving H, Brunnström H, O'Reilly A, Bosic M, Gulyas M, Isaksson J, Botling J, Kärre K, Jirström K, Lamberg K, Pontén F, Leandersson K, Mezheyeuski A, Micke P. Backman M, et al. Among authors: lindberg a. Eur J Cancer. 2023 May;185:40-52. doi: 10.1016/j.ejca.2023.02.012. Epub 2023 Feb 24. Eur J Cancer. 2023. PMID: 36963351 Free article.
An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers.
Mezheyeuski A, Backman M, Mattsson J, Martín-Bernabé A, Larsson C, Hrynchyk I, Hammarström K, Ström S, Ekström J, Mauchanski S, Khelashvili S, Lindberg A, Agnarsdóttir M, Edqvist PH, Huvila J, Segersten U, Malmström PU, Botling J, Nodin B, Hedner C, Borg D, Brändstedt J, Sartor H, Leandersson K, Glimelius B, Portyanko A, Ponten F, Jirström K, Micke P, Sjöblom T. Mezheyeuski A, et al. Among authors: lindberg a. EBioMedicine. 2023 Feb;88:104452. doi: 10.1016/j.ebiom.2023.104452. Epub 2023 Jan 30. EBioMedicine. 2023. PMID: 36724681 Free PMC article.
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.
Fernández Moro C, Geyer N, Harrizi S, Hamidi Y, Söderqvist S, Kuznyecov D, Tidholm Qvist E, Salmonson Schaad M, Hermann L, Lindberg A, Heuchel RL, Martín-Bernabé A, Dhanjal S, Navis AC, Villard C, Del Valle AC, Bozóky L, Sparrelid E, Dirix L, Strell C, Östman A, Schmierer B, Vermeulen PB, Engstrand J, Bozóky B, Gerling M. Fernández Moro C, et al. Among authors: lindberg a. Nat Commun. 2023 Aug 18;14(1):5024. doi: 10.1038/s41467-023-40688-x. Nat Commun. 2023. PMID: 37596278 Free PMC article.
Loss of chromosome Y in regulatory T cells.
Mattisson J, Halvardson J, Davies H, Bruhn-Olszewska B, Olszewski P, Danielsson M, Bjurling J, Lindberg A, Zaghlool A, Rychlicka-Buniowska E, Dumanski JP, Forsberg LA. Mattisson J, et al. Among authors: lindberg a. BMC Genomics. 2024 Mar 5;25(1):243. doi: 10.1186/s12864-024-10168-7. BMC Genomics. 2024. PMID: 38443832 Free PMC article.
Tumour-infiltrating lymphocytes add prognostic information for patients with low-risk DCIS: findings from the SweDCIS randomised radiotherapy trial.
Schiza A, Thurfjell V, Stenmark Tullberg A, Olofsson H, Lindberg A, Holmberg E, Bremer T, Micke P, Karlsson P, Wärnberg F, Strell C. Schiza A, et al. Among authors: lindberg a. Eur J Cancer. 2022 Jun;168:128-137. doi: 10.1016/j.ejca.2022.01.016. Epub 2022 Feb 27. Eur J Cancer. 2022. PMID: 35236568 Free article. Clinical Trial.
Loss of Nexilin function leads to a recessive lethal fetal cardiomyopathy characterized by cardiomegaly and endocardial fibroelastosis.
Johansson J, Frykholm C, Ericson K, Kazamia K, Lindberg A, Mulaiese N, Falck G, Gustafsson PE, Lidéus S, Gudmundsson S, Ameur A, Bondeson ML, Wilbe M. Johansson J, et al. Among authors: lindberg a. Am J Med Genet A. 2022 Jun;188(6):1676-1687. doi: 10.1002/ajmg.a.62685. Epub 2022 Feb 15. Am J Med Genet A. 2022. PMID: 35166435 Free PMC article.
Infiltration of NK and plasma cells is associated with a distinct immune subset in non-small cell lung cancer.
Backman M, La Fleur L, Kurppa P, Djureinovic D, Elfving H, Brunnström H, Mattsson JSM, Lindberg A, Pontén V, Eltahir M, Mangsbo S, Gulyas M, Isaksson J, Jirström K, Kärre K, Leandersson K, Mezheyeuski A, Pontén F, Strell C, Lindskog C, Botling J, Micke P. Backman M, et al. Among authors: lindberg a. J Pathol. 2021 Nov;255(3):243-256. doi: 10.1002/path.5772. Epub 2021 Aug 26. J Pathol. 2021. PMID: 34339045
PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung.
Goldmann T, Marwitz S, Nitschkowski D, Krupar R, Backman M, Elfving H, Thurfjell V, Lindberg A, Brunnström H, La Fleur L, Mezheyeuski A, Mattsson JSM, Botling J, Micke P, Strell C. Goldmann T, et al. Among authors: lindberg a. Cancer Immunol Immunother. 2021 Sep;70(9):2577-2587. doi: 10.1007/s00262-020-02825-z. Epub 2021 Feb 12. Cancer Immunol Immunother. 2021. PMID: 33576873 Free PMC article.