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The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems.
Behm DJ, Stankus G, Doe CP, Willette RN, Sarau HM, Foley JJ, Schmidt DB, Nuthulaganti P, Fornwald JA, Ames RS, Lambert DG, Calo' G, Camarda V, Aiyar NV, Douglas SA. Behm DJ, et al. Among authors: ames rs. Br J Pharmacol. 2006 May;148(2):173-90. doi: 10.1038/sj.bjp.0706716. Br J Pharmacol. 2006. PMID: 16547525 Free PMC article.
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW. Sarau HM, et al. Among authors: ames rs. Mol Pharmacol. 1999 Sep;56(3):657-63. doi: 10.1124/mol.56.3.657. Mol Pharmacol. 1999. PMID: 10462554
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA. Ames RS, et al. Nature. 1999 Sep 16;401(6750):282-6. doi: 10.1038/45809. Nature. 1999. PMID: 10499587
71 results